TICAM2 and IRF7

Data Source:
HPRD (in vivo)

		TICAM2	IRF7
Description		toll like receptor adaptor molecule 2	interferon regulatory factor 7
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GO Annotations	Cellular Component	Phagocytic Cup Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Endosome Membrane COPII-coated ER To Golgi Transport Vesicle Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phagocytosis Inflammatory Response Golgi Organization I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Innate Immune Response Necroptotic Process Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Response To Virus Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-alpha Production Interferon-beta Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways		Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)	Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)
Interacting Genes		19 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6	27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B
Entrez ID		353376	3665
HPRD ID		16313	05441
Ensembl ID		ENSG00000243414	ENSG00000185507
Uniprot IDs		Q86XR7	A0A024RCA2 B4E1B1 M9RSF4 Q92985
PDB IDs		2M1W	2O61
Enriched GO Terms of Interacting Partners?
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