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NBPF19 and HHEX
Data Source:
BioGRID
(two hybrid)
NBPF19
HHEX
Description
NBPF member 19
hematopoietically expressed homeobox
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Chromatin
Nucleus
Cytoplasm
Protein-DNA Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Transcription Factor Binding
Eukaryotic Initiation Factor 4E Binding
DNA Binding, Bending
TBP-class Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Repressing Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
MRNA Export From Nucleus
Response To Wounding
Anterior/posterior Pattern Specification
Negative Regulation Of Transcription By Transcription Factor Localization
Negative Regulation Of Transcription By Competitive Promoter Binding
Wnt Signaling Pathway
Negative Regulation Of Angiogenesis
Poly(A)+ MRNA Export From Nucleus
Cell Differentiation
Positive Regulation Of Wnt Signaling Pathway
B Cell Differentiation
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Protein Localization To Nucleus
Response To Peptide Hormone
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Leukocyte Proliferation
DNA Conformation Change
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
Type II diabetes mellitus
GWAS
Serum uric acid levels (
30993211
)
Age-related cognitive decline (attention/processing speed) (slope of z-scores) (
30954325
)
Asthma (
31619474
)
Birth weight (
31043758
27680694
)
Body mass index (
28892062
)
Circulating leptin levels or type 2 diabetes (
32341051
)
Corrected insulin response (
24699409
)
Corrected insulin response adjusted for insulin sensitivity index (
24699409
)
Dehydroepiandrosterone sulphate levels (
21533175
)
Eosinophil counts (
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Hemoglobin A1c levels (
29403010
)
Inflammatory bowel disease (
28067908
)
Insulin disposition index (
24699409
)
Insulin levels in response to oral glucose tolerance test (30 minutes) (
29093273
)
Intraocular pressure (
29785010
)
Multiple sclerosis (
31604244
24076602
21833088
)
Sum eosinophil basophil counts (
27863252
)
Systolic blood pressure (
30224653
)
Type 2 diabetes (
22885922
18372903
24509480
17293876
30054458
22693455
20862305
29358691
30297969
26818947
23945395
32499647
20581827
19401414
17463246
30718926
17463248
17463249
28869590
)
Interacting Genes
223 interacting genes:
ADAM12
ADAMTSL4
AGXT
ALDH16A1
ALPP
ANKS1A
AQP1
ATG9A
ATP5F1D
BCAM
BMP7
BRME1
CARHSP1
CATSPER1
CCER1
CD164
CELF5
CERK
CHCHD3
CHIC2
CHRD
CHRNG
CNNM3
COL8A1
CREB5
CRH
CRY2
CST2
CST9L
CTNNBIP1
CTSZ
CXCL16
CYHR1
CYP21A2
CYSRT1
DAGLB
DALRD3
DBH
DGKQ
DHRS1
DMRT3
DOCK2
DRD5
EMC7
F10
FADS2
FAM221A
FAM71C
FAM90A1
FBXW5
FRS3
FTHL17
FZD10
GLP1R
GLYAT
GNE
GSTP1
HAPLN2
HBA1
HBA2
HBZ
HCK
HHEX
HOXA1
HOXB9
HOXC8
HPCAL1
HSPA12B
ICAM4
IL10
INO80B
INS
ITGB2
ITGB4
ITGB5
JOSD1
KCNS2
KCTD15
KLHL38
KLK8
KPRP
KRT83
KRTAP10-1
KRTAP10-10
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP13-3
KRTAP13-4
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP4-11
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-8
LCE1A
LCE1B
LCE1D
LCE1E
LCE1F
LCE2B
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LMNTD2
LNX1
LRFN4
LYVE1
MACO1
MAPKBP1
MELTF
MFSD13A
MOS
MRGBP
MRPL40
MTA1
MXD3
MXI1
MYO15B
MYPOP
NECTIN2
NECTIN3
NEDD9
NMU
NPDC1
NR1D2
NTM
NTN4
OLFM2
OTX1
P2RX4
P2RX7
P2RY6
PCSK5
PGAP6
PHLDA1
PIGS
PLEKHN1
PRF1
PRR35
PSMA1
PTK7
PTPMT1
PVR
R3HDM2
RAB3IL1
RAMP3
RASD1
RECK
RNF111
RPS19BP1
RTN4RL1
SCNM1
SEMA3B
SEMA4C
SHFL
SLC22A5
SLC23A1
SLC43A2
SLC5A5
SLC6A20
SMCP
SPATA24
SPATA8
SPG7
SPPL2C
SPRY1
STAC
STK16
TAPBPL
TCAF1
THAP7
TLE5
TMEFF2
TMEM150A
TMIE
TNIP3
TNS2
TRAPPC14
TRIM42
TROAP
TSPAN4
TTPA
UTP23
UXT
VASN
WDR25
ZDHHC1
ZNF124
ZNF319
ZNF330
ZNF408
ZNF414
ZNF417
ZNF440
ZNF446
ZNF497
ZNF580
ZNF581
ZNF587
ZNF648
ZNF672
ZNF786
ZNF837
40 interacting genes:
ABI1
ABI2
APOBEC3C
CYSRT1
EFEMP2
GATA2
GATA6
JUN
KHDRBS2
KRTAP1-3
KRTAP10-3
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP19-1
KRTAP2-3
KRTAP2-4
KRTAP4-12
KRTAP5-7
KRTAP5-8
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
MDFI
NBPF19
NOTCH2NLA
PFDN5
PML
PSMA3
PSTPIP1
RBMY1F
RBMY1J
SOX10
SOX8
TLE1
TLE5
TP53BP2
TRMT6
Entrez ID
101060226
3087
HPRD ID
06829
Ensembl ID
ENSG00000271383
ENSG00000152804
Uniprot IDs
Q03014
PDB IDs
2E1O
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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