ING1 and YWHAH

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		ING1	YWHAH
Description		inhibitor of growth family member 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
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GO Annotations	Cellular Component	Nucleus	Cytoplasm Mitochondrion Cytosol Plasma Membrane Intercalated Disc Extracellular Exosome
	Molecular Function	Protein Binding Methylated Histone Binding Metal Ion Binding	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Identical Protein Binding Ion Channel Binding Protein Heterodimerization Activity
	Biological Process	Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Cell Death Negative Regulation Of Cell Growth Positive Regulation Of Transcription, DNA-templated	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Substantia Nigra Development Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Organization Membrane Depolarization During Action Potential Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Blood protein levels ( 30072576) Erosive tooth wear (severe vs non-severe) ( 29898447)	Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		29 interacting genes: BRMS1 BRMS1L COPS2 CYTOR DMAP1 EP300 ESR1 EXOC4 H3C14 HDAC1 HDAC2 KAT2B MRGBP NQO1 PCNA RBBP4 RBBP7 RBP1 SAP30 SFN SIN3A TP53 UBC YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	66 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		3621	7533
HPRD ID		03337	00215
Ensembl ID		ENSG00000153487	ENSG00000128245
Uniprot IDs		A0A0C4DFW2 Q9UK53	A0A024R1K7 Q04917 Q9H4N8
PDB IDs		2QIC	2C63 2C74
Enriched GO Terms of Interacting Partners?
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