IL13RA2 and PALB2

Data Source:
BioGRID (two hybrid)

		IL13RA2	PALB2
Description		interleukin 13 receptor subunit alpha 2	partner and localizer of BRCA2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Nucleoplasm
	Molecular Function	Cytokine Receptor Activity Protein Binding Cytokine Binding	DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		Interleukin-4 and Interleukin-13 signaling	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs		AER001
Diseases			Fanconi anemia
GWAS			Bipolar disorder ( 17554300)
Interacting Genes		17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		3598	79728
HPRD ID		02132	07966
Ensembl ID		ENSG00000123496	ENSG00000083093
Uniprot IDs		Q14627	H3BN63 Q86YC2
PDB IDs		3LB6	2W18 3EU7
Enriched GO Terms of Interacting Partners?
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