IL10RA and IL10RB

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		IL10RA	IL10RB
Description		interleukin 10 receptor subunit alpha	interleukin 10 receptor subunit beta
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-10 Receptor Activity Protein Binding Interleukin-10 Binding Signaling Receptor Activity	Cytokine Receptor Activity Interleukin-10 Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Autophagy Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Synapse Organization Ubiquitin-dependent Endocytosis	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus
Pathways		Interleukin-10 signaling	Other interleukin signaling Interleukin-10 signaling Interleukin-20 family signaling
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Blood protein levels ( 30072576) Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Narcolepsy ( 24204295 23459209)
Interacting Genes		20 interacting genes: BTRC C1QL4 CDS2 CMTM3 HACD1 IL10 IL10RB JAK1 MAL NIPAL4 PLPP6 RUSF1 SELENOK SLC38A7 SLC66A2 SLC7A14 SMCO4 TMEM242 TMUB2 YIPF6	7 interacting genes: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3
Entrez ID		3587	3588
HPRD ID		00911	00473
Ensembl ID		ENSG00000110324	ENSG00000243646
Uniprot IDs		Q13651	Q08334
PDB IDs		1J7V 1LQS 1Y6K 1Y6M 1Y6N 5IXI	3LQM 5T5W
Enriched GO Terms of Interacting Partners?
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