IL10RB and IL10

Data Source:
HPRD (in vivo, in vitro)

		IL10RB	IL10
Description		interleukin 10 receptor subunit beta	interleukin 10
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Interleukin-10 Receptor Activity Protein Binding Signaling Receptor Activity	Cytokine Activity Interleukin-10 Receptor Binding Protein Binding Growth Factor Activity Protein Dimerization Activity
	Biological Process	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Defense Response To Virus	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Response To Molecule Of Bacterial Origin Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Aging Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Autophagy Response To Activity Response To Inactivity Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Response To Carbon Monoxide Interleukin-12-mediated Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Response To Drug Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Glucocorticoid Negative Regulation Of Cytokine Activity Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Endothelial Cell Apoptotic Process Liver Regeneration Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Response To Wounding Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Sensory Perception Of Pain Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Other interleukin signaling Interleukin-10 signaling Interleukin-20 family signaling	Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis
Drugs			CRx-139 LLL-3348
Diseases			Graft-versus-host disease Allograft rejection
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 23128233) Multiple sclerosis ( 31604244) Narcolepsy ( 24204295 23459209)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Behcet's disease ( 20622878 20622879) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28008999 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Pediatric autoimmune diseases ( 26301688) Systemic lupus erythematosus ( 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 30572963) Ulcerative colitis ( 19915572 28067908 26398853 20228798 20228799 18836448 21297633)
Interacting Genes		7 interacting genes: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3	10 interacting genes: A2M GLRX3 IL10RA IL10RB KRTAP1-3 KRTAP10-8 KRTAP4-1 NBPF19 NOTCH2NLA YY1
Entrez ID		3588	3586
HPRD ID		00473	00495
Ensembl ID		ENSG00000243646	ENSG00000136634
Uniprot IDs		Q08334	P22301 Q6FGW4
PDB IDs		3LQM 5T5W	1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK
Enriched GO Terms of Interacting Partners?
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