IL10 and A2M

Data Source:
HPRD (in vitro)

		IL10	A2M
Description		interleukin 10	alpha-2-macroglobulin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Cytokine Activity Interleukin-10 Receptor Binding Protein Binding Growth Factor Activity Protein Dimerization Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Response To Molecule Of Bacterial Origin Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Aging Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Autophagy Response To Activity Response To Inactivity Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Response To Carbon Monoxide Interleukin-12-mediated Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Response To Drug Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Glucocorticoid Negative Regulation Of Cytokine Activity Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Endothelial Cell Apoptotic Process Liver Regeneration Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Response To Wounding Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Sensory Perception Of Pain Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly
Drugs		CRx-139 LLL-3348	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Graft-versus-host disease Allograft rejection
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Behcet's disease ( 20622878 20622879) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28008999 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Pediatric autoimmune diseases ( 26301688) Systemic lupus erythematosus ( 26502338 28714469 19838195) Type 1 diabetes ( 21829393 25751624 19430480 30572963) Ulcerative colitis ( 19915572 28067908 26398853 20228798 20228799 18836448 21297633)	Refractive error ( 32231278)
Interacting Genes		10 interacting genes: A2M GLRX3 IL10RA IL10RB KRTAP1-3 KRTAP10-8 KRTAP4-1 NBPF19 NOTCH2NLA YY1	96 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS
Entrez ID		3586	2
HPRD ID		00495	00072
Ensembl ID		ENSG00000136634	ENSG00000175899
Uniprot IDs		P22301 Q6FGW4	P01023
PDB IDs		1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?
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