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AQP1 and CCDC57
Data Source:
BioGRID
(two hybrid)
AQP1
CCDC57
Description
aquaporin 1 (Colton blood group)
coiled-coil domain containing 57
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Brush Border
Basal Plasma Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Symbiont-containing Vacuole Membrane
Brush Border Membrane
Nuclear Membrane
Sarcolemma
Apical Part Of Cell
Extracellular Exosome
Centrosome
Centriole
Spindle Microtubule
Centriolar Satellite
Molecular Function
Intracellular CGMP-activated Cation Channel Activity
Potassium Channel Activity
Water Transmembrane Transporter Activity
Protein Binding
Ammonium Transmembrane Transporter Activity
Potassium Ion Transmembrane Transporter Activity
Glycerol Transmembrane Transporter Activity
Water Channel Activity
Transmembrane Transporter Activity
Nitric Oxide Transmembrane Transporter Activity
Carbon Dioxide Transmembrane Transporter Activity
Identical Protein Binding
Protein Binding
Biological Process
Renal Water Homeostasis
Renal Water Transport
Potassium Ion Transport
Water Transport
Cell Volume Homeostasis
Hyperosmotic Response
Cellular Water Homeostasis
Carbon Dioxide Transport
Ammonium Transport
Bicarbonate Transport
Glycerol Transport
Cellular Homeostasis
CGMP-mediated Signaling
Lateral Ventricle Development
Pancreatic Juice Secretion
Nitric Oxide Transport
Establishment Or Maintenance Of Actin Cytoskeleton Polarity
Cerebrospinal Fluid Secretion
Cellular Response To UV
Transepithelial Water Transport
Carbon Dioxide Transmembrane Transport
Odontogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Saliva Secretion
Positive Regulation Of Fibroblast Proliferation
Defense Response To Gram-negative Bacterium
Multicellular Organismal Water Homeostasis
Cellular Response To Hydrogen Peroxide
Cellular Response To Inorganic Substance
Cellular Response To Mechanical Stimulus
Cellular Response To Copper Ion
Cellular Response To Mercury Ion
Cellular Response To Retinoic Acid
Cellular Response To CAMP
Cellular Response To Hypoxia
Cellular Response To Salt Stress
Cellular Hyperosmotic Response
Cellular Response To Dexamethasone Stimulus
Cellular Response To Nitric Oxide
Potassium Ion Transmembrane Transport
Ammonium Transmembrane Transport
Maintenance Of Symbiont-containing Vacuole By Host
G2/M Transition Of Mitotic Cell Cycle
Microtubule Nucleation
Centriole Replication
Positive Regulation Of Mitotic Cell Cycle
Cilium Assembly
Pathways
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Vasopressin regulates renal water homeostasis via Aquaporins
Passive transport by Aquaporins
Drugs
Acetazolamide
B-nonylglucoside
Mersalyl
Diseases
GWAS
Fractures (
30598549
)
Heel bone mineral density (
30598549
28869591
)
Huntington's disease progression (
28642124
)
Kidney stones (
31729369
)
Nephrolithiasis (
22396660
)
Systolic blood pressure (
30224653
)
Total body bone mineral density (
29304378
)
Blood metabolite levels (
24816252
)
Blood urea nitrogen levels (
31152163
)
Proteinuria and chronic kidney disease (
26420894
)
Refractive error (
32231278
)
Interacting Genes
134 interacting genes:
ADAMTSL4
AMOT
AQP6
BCL2L13
BEGAIN
BHLHB9
BLZF1
BMF
CCDC136
CCDC57
CCDC85B
CCNDBP1
CD79A
CDR2
CEP44
CLDN5
COMP
CPLX4
CREB3
CRTAC1
CSRNP1
CYSRT1
EFEMP2
EPHB2
ESM1
EVI2B
FAM161A
FAM209A
FNDC9
FOS
FSD2
GET1
GJB5
GLI1
GOLGA2
GPR37L1
GPX8
IFT20
IGFBP6
IHO1
IKZF2
IKZF3
IL21R
KCNK5
KCTD17
KCTD9
KHDRBS3
KIAA1958
KLHL26
KRT31
KRT33B
KRT37
KRT40
KRTAP1-1
KRTAP1-5
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP12-4
KRTAP3-2
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP6-2
KRTAP9-2
KRTAP9-8
LCE1A
LDLRAD1
LDOC1
LIME1
LMNA
LPXN
LRRC59
MDFI
MGST3
MID2
MIF4GD
MKRN3
MRM1
MTUS2
MUC1
MYF5
NBPF19
NBPF22P
NBPF6
NOTCH2NLA
NUTM1
PGPEP1
PICK1
PLA2G10
PLSCR2
PPARA
PRDM14
PRDM6
RBAK
REL
RGS17
RGS20
RIMBP3
RNF122
SAR1A
SIAH1
SIVA1
SLC15A2
SLC39A2
SPDYA
SPRED1
SPRED2
SPRY2
SPRY3
SPRYD7
SSMEM1
TCF4
TMEM237
TMEM38B
TMEM45B
TMEM80
TMPRSS2
TNK2
TNS2
TRAF1
TRAF2
TRIM23
TRIM37
TRIM41
TRIM42
TRIM7
TRIP6
TSC1
ZBTB39
ZIM2
ZNF16
ZNF398
ZNF792
148 interacting genes:
ABI1
ABI2
ABLIM1
AMOTL2
ANKRD23
AQP1
ARID5A
ARL4A
AXIN1
BCAR3
BEX2
C19orf44
C2CD6
C4orf45
C9orf24
CBX8
CBY2
CCDC120
CCDC33
CDC20B
CEP57L1
CFAP53
COIL
CRTC2
CWF19L2
DCLK2
DISC1
DTX2
ECPAS
EFHC2
EIF3D
EIF4G1
ELOA
EMILIN3
ESS2
FAM107A
FAM161A
FAM161B
FAM228A
FAM50B
FAM90A1
FH
FOXD4L1
FTO
GFAP
GIGYF1
GPBP1
GPKOW
GRPEL1
HAUS1
HBA2
HDX
IHO1
IKZF3
INCA1
INTS2
JRK
KANK2
KIAA0408
KLF1
KLF15
KPRP
KRT4
KRT76
KRTAP13-2
KRTAP13-3
LENG1
LINC00526
LZTS1
MAD1L1
MDM1
MFAP1
MT1E
MYOZ3
NAB2
NAPRT
NCOA5
NELFE
NME4
NUMA1
PAK5
PER1
POM121
PPHLN1
PPP1R18
PPP1R32
PRAM1
PRDM6
PROSER3
PRPF18
PRPF31
PRR3
PSMB4
PTCHD3
PTPN7
RAB3IL1
RASD1
RBM48
RDM1
RINT1
RNF6
ROBO3
RUSC1
RXRB
SFI1
SH3KBP1
SHISA6
SIRPA
SLC25A48
SMG9
SNRNP35
SORBS3
SPRY1
SYT6
TBC1D22B
TCP10L
TFIP11
TFPT
TIMM44
TLE5
TMEM100
TNNI1
TP53BP2
TRIM14
TRIM29
TSEN54
TSGA10IP
TSHZ2
TXLNA
USP15
USP2
UTP14C
VPS52
YJU2
ZBTB4
ZC2HC1C
ZFC3H1
ZGPAT
ZMAT2
ZNF417
ZNF436
ZNF474
ZNF552
ZNF648
ZNF655
ZNF688
ZNF835
ZSWIM3
Entrez ID
358
284001
HPRD ID
00140
14150
Ensembl ID
ENSG00000240583
ENSG00000176155
Uniprot IDs
A0A024RA31
P29972
A0A590UJT6
Q2TAC2
PDB IDs
1FQY
1H6I
1IH5
4CSK
6POJ
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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