IRF7 and TBK1

Data Source:
BioGRID (pull down)

		IRF7	TBK1
Description		interferon regulatory factor 7	TANK binding kinase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane	Nucleoplasm Cytoplasm Cytosol Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Response To Virus Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-alpha Production Interferon-beta Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Activation Of Innate Immune Response Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Viral Process Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Neuron Death Positive Regulation Of Xenophagy
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Potential therapeutics for SARS
Drugs			Fostamatinib
Diseases
GWAS		Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)	Amyotrophic lateral sclerosis ( 29566793 27455348) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung adenocarcinoma ( 28604730) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B	44 interacting genes: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG CYLD HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 MAP1LC3B MAVS MBP MIB2 MTPAP NCK1 NEDD4 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SIKE1 SMCR8 SMURF1 SQSTM1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TRIM27 TXLNG XIAP
Entrez ID		3665	29110
HPRD ID		05441	05322
Ensembl ID		ENSG00000185507	ENSG00000183735
Uniprot IDs		A0A024RCA2 B4E1B1 M9RSF4 Q92985	Q9UHD2
PDB IDs		2O61	4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B 6RSR 6RST 6RSU
Enriched GO Terms of Interacting Partners?
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