IRF7 and TRMT61B

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		IRF7	TRMT61B
Description		interferon regulatory factor 7	tRNA methyltransferase 61B
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane	Mitochondrion Mitochondrial Matrix TRNA (m1A) Methyltransferase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding TRNA (adenine-N1-)-methyltransferase Activity RRNA (adenine) Methyltransferase Activity MRNA (adenine-N1-)-methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Response To Virus Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-alpha Production Interferon-beta Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	TRNA Methylation RRNA Methylation Protein Homooligomerization Mitochondrial TRNA Methylation MRNA Methylation
Pathways		DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	tRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Intraocular pressure ( 29617998)
Interacting Genes		27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B	3 interacting genes: FAM9B IRF7 PPP2CB
Entrez ID		3665	55006
HPRD ID		05441	07935
Ensembl ID		ENSG00000185507	ENSG00000171103
Uniprot IDs		A0A024RCA2 B4E1B1 M9RSF4 Q92985	Q9BVS5
PDB IDs		2O61	2B25
Enriched GO Terms of Interacting Partners?
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