IGHA1 and RNF115

Data Source:
BioGRID (two hybrid)

		IGHA1	RNF115
Description		immunoglobulin heavy constant alpha 1	ring finger protein 115
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Monomeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Blood Microparticle	Cytosol
	Molecular Function	Antigen Binding Immunoglobulin Receptor Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Retina Homeostasis Glomerular Filtration Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Complement Activation, Classical Pathway Protein-chromophore Linkage Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Leukocyte Migration Positive Regulation Of Respiratory Burst	Protein Polyubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Composite immunoglobulin trait (IgA/IgG) ( 28628107) Composite immunoglobulin trait (IgA/IgM) ( 28628107)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)
Interacting Genes		3 interacting genes: FYN LYN RNF115	32 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2
Entrez ID		3493	27246
HPRD ID			18328
Ensembl ID		ENSG00000211895	ENSG00000265491
Uniprot IDs			Q9Y4L5
PDB IDs
Enriched GO Terms of Interacting Partners?
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