IGF2R and GZMB

Data Source:
HPRD (in vitro)

		IGF2R	GZMB
Description		insulin like growth factor 2 receptor	granzyme B
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GO Annotations	Cellular Component	Nuclear Envelope Lumen Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Clathrin-coated Vesicle Membrane Secretory Granule Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor-activated Receptor Activity Protein Binding Insulin-like Growth Factor Binding Mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding Retromer Complex Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Positive Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation By Host Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Membrane Organization Response To Tetrachloromethane	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria
Drugs		Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa Mecasermin rinfabate
Diseases		Hepatocellular carcinoma
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain lesion load ( 19010793) Coronary artery disease ( 29212778) LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 26377243) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Periodontitis (CDC/AAP) ( 24024966) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)
Interacting Genes		14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		3482	3002
HPRD ID		00928	00476
Ensembl ID		ENSG00000197081	ENSG00000100453
Uniprot IDs		P11717	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs		1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32	1FQ3 1IAU
Enriched GO Terms of Interacting Partners?
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