IGFBP2 and KLK2

Data Source:
HPRD (in vitro)

		IGFBP2	KLK2
Description		insulin like growth factor binding protein 2	kallikrein related peptidase 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome	Extracellular Region Secretory Granule Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Serine-type Endopeptidase Activity
	Biological Process	Signal Transduction Female Pregnancy Aging Response To Nutrient Response To Mechanical Stimulus Response To Lithium Ion Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Regulation Of Growth Positive Regulation Of Activated T Cell Proliferation Response To Drug Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Cellular Protein Metabolic Process Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Diseases
GWAS		Glomerular filtration rate (creatinine) ( 28452372) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Mitral valve prolapse ( 26301497) Thyroid stimulating hormone levels ( 25743335) Type 2 diabetes ( 26818947)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		6 interacting genes: GSDMB IGF1 IGF2 INO80B KLK2 TF	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		3485	3817
HPRD ID		00898	01006
Ensembl ID		ENSG00000115457	ENSG00000167751
Uniprot IDs		C9JMY1 P18065	A0A024R4J4 A0A024R4N3 B4DU77 P20151
PDB IDs		2H7T	4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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