Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
FAM174A and TREX1
Data Source:
BioGRID
(two hybrid)
FAM174A
TREX1
Description
family with sequence similarity 174 member A
three prime repair exonuclease 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Membrane
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Oligosaccharyltransferase Complex
Protein-DNA Complex
Nuclear Replication Fork
Molecular Function
Protein Binding
Magnesium Ion Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
3'-5'-exodeoxyribonuclease Activity
DNA Binding, Bending
3'-5' Exonuclease Activity
Exodeoxyribonuclease III Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Adenyl Deoxyribonucleotide Binding
Protein Homodimerization Activity
Metal Ion Binding
WW Domain Binding
Biological Process
DNA Catabolic Process, Exonucleolytic
Blood Vessel Development
Kidney Development
Activation Of Immune Response
Macrophage Activation Involved In Immune Response
Lymphoid Progenitor Cell Differentiation
Immune Response In Brain Or Nervous System
Inflammatory Response To Antigenic Stimulus
T Cell Antigen Processing And Presentation
Regulation Of Immunoglobulin Production
Heart Morphogenesis
Heart Process
Atrial Cardiac Muscle Tissue Development
Generation Of Precursor Metabolites And Energy
Regulation Of Glycolytic Process
DNA Metabolic Process
DNA Replication
DNA Repair
Mismatch Repair
DNA Modification
DNA Recombination
Determination Of Adult Lifespan
Regulation Of Fatty Acid Metabolic Process
Transposition, RNA-mediated
Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Regulation Of Tumor Necrosis Factor Production
Cellular Response To Reactive Oxygen Species
Cellular Response To Interferon-beta
CD86 Biosynthetic Process
Apoptotic Cell Clearance
Regulation Of Cellular Respiration
Establishment Of Protein Localization
Regulation Of Lipid Biosynthetic Process
Regulation Of Inflammatory Response
Regulation Of Catalytic Activity
Protein Stabilization
Regulation Of T Cell Activation
Defense Response To Virus
Type I Interferon Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of Protein Complex Stability
Cellular Response To Gamma Radiation
Detection Of Stimulus Involved In Cell Cycle Checkpoint
Detection Of DNA Damage Stimulus Involved In DNA Damage Checkpoint
Signal Transduction Involved In DNA Damage Checkpoint
Cellular Response To Hydroxyurea
Immune Complex Formation
DNA Synthesis Involved In UV-damage Excision Repair
Regulation Of Lysosome Organization
Pathways
Regulation by TREX1
IRF3-mediated induction of type I IFN
Drugs
Diseases
Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE)
Aicardi-Goutieres Syndrome (AGS)
Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS
Heel bone mineral density (
30598549
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Obesity-related traits (
23251661
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Interacting Genes
36 interacting genes:
ANKRD46
BET1
BNIP1
C14orf180
C4orf3
CCDC167
CMTM7
DEFB127
ERG28
FKBP8
GIMAP1
GIMAP5
GOSR2
HMOX1
LCK
PLLP
PLPP6
RTP2
SEC22A
SEC22B
SERP1
SLC30A2
SMCO4
SMIM1
STX7
STX8
TMEM11
TMEM203
TMEM222
TMEM239
TMEM243
TMEM42
TMEM65
TREX1
VAMP3
VAPB
46 interacting genes:
AQP6
ATM
ATR
CD81
CHCHD2
CLDN22
CRB3
CYB561
CYSRT1
EBP
ELOVL4
FAM174A
FFAR3
FNDC9
GJA5
GKN1
GPR42
HSD17B13
IFNGR2
IFT20
JAGN1
KRTAP10-7
MCM7
MFSD14B
MSH2
NBN
PEX12
PRKDC
PRND
RELL1
RIBC2
RNASEK
RPA1
SEC11C
SET
SLC10A6
SLC22A2
SLC7A14
TM4SF18
TMEM205
TMEM207
TMEM45B
TMEM86B
TMX2
UBQLN1
VKORC1
Entrez ID
345757
11277
HPRD ID
18260
09423
Ensembl ID
ENSG00000174132
ENSG00000213689
Uniprot IDs
Q8TBP5
Q5TZT0
Q9NSU2
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?