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FAM174A and VAPB
Data Source:
BioGRID
(two hybrid)
FAM174A
VAPB
Description
family with sequence similarity 174 member A
VAMP associated protein B and C
Image
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Membrane
Golgi Membrane
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Membrane
Endoplasmic Reticulum Exit Site
Molecular Function
Protein Binding
Protein Binding
Microtubule Binding
Enzyme Binding
FFAT Motif Binding
Protein Homodimerization Activity
Cadherin Binding
Protein Heterodimerization Activity
Beta-tubulin Binding
Biological Process
Cellular Calcium Ion Homeostasis
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Endoplasmic Reticulum Organization
Modulation By Virus Of Host Process
Sphingolipid Biosynthetic Process
Endoplasmic Reticulum Unfolded Protein Response
IRE1-mediated Unfolded Protein Response
Positive Regulation Of Viral Genome Replication
Endoplasmic Reticulum-plasma Membrane Tethering
COPII-coated Vesicle Budding
Endoplasmic Reticulum Membrane Organization
Pathways
Sphingolipid de novo biosynthesis
Drugs
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS
Heel bone mineral density (
30598549
)
Interacting Genes
36 interacting genes:
ANKRD46
BET1
BNIP1
C14orf180
C4orf3
CCDC167
CMTM7
DEFB127
ERG28
FKBP8
GIMAP1
GIMAP5
GOSR2
HMOX1
LCK
PLLP
PLPP6
RTP2
SEC22A
SEC22B
SERP1
SLC30A2
SMCO4
SMIM1
STX7
STX8
TMEM11
TMEM203
TMEM222
TMEM239
TMEM243
TMEM42
TMEM65
TREX1
VAMP3
VAPB
41 interacting genes:
AIG1
AQP2
AQP6
CD79A
CYB561
CYBRD1
EBAG9
EBP
ELOVL4
EMD
FAM174A
GLP1R
GPR25
HSD17B13
JAGN1
KCNB1
MTNR1A
OSBPL2
PTGES
REEP4
RETREG3
RMDN2
RNASEK
RNF111
SCN3B
SLC22A1
SLC35C2
STX1A
STX2
STX4
STX5
TMEM101
TMX2
TTC39B
USP20
VAMP1
VAMP2
VHL
VKORC1
ZBTB22
ZDHHC15
Entrez ID
345757
9217
HPRD ID
18260
09300
Ensembl ID
ENSG00000174132
ENSG00000124164
Uniprot IDs
Q8TBP5
O95292
Q53XM7
PDB IDs
2MDK
3IKK
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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