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ANKRD11 and HDAC5
Data Source:
HPRD
(in vitro)
ANKRD11
HDAC5
Description
ankyrin repeat domain 11
histone deacetylase 5
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Nuclear Speck
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
Chromatin Binding
Histone Deacetylase Activity
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Identical Protein Binding
Histone Deacetylase Binding
Metal Ion Binding
Repressing Transcription Factor Binding
Biological Process
Anatomical Structure Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Skeletal System Morphogenesis
Face Morphogenesis
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
Chromatin Silencing
Protein Deacetylation
Inflammatory Response
Regulation Of Myotube Differentiation
Negative Regulation Of Myotube Differentiation
Response To Activity
Histone Deacetylation
Neuron Differentiation
B Cell Differentiation
Cellular Response To Insulin Stimulus
Regulation Of Gene Expression, Epigenetic
B Cell Activation
Response To Cocaine
Response To Drug
Regulation Of Protein Binding
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Histone H3 Deacetylation
Cellular Response To Lipopolysaccharide
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Histone H3-K9 Acetylation
Pathways
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
Regulation of PTEN gene transcription
Drugs
Belinostat
Panobinostat
Diseases
GWAS
Eosinophil counts (
32888494
)
Hemoglobin levels (
32327693
)
Lymphocyte counts (
32888494
27863252
)
Monocyte count (
32888494
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
31043756
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (spine) (
19801982
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
28869591
)
Mean platelet volume (
32888494
)
Interacting Genes
93 interacting genes:
ABHD11
AGR2
ANKRD33
ARID3A
ARID5A
BHLHB9
BRCC3
C10orf82
C11orf1
C18orf54
C1QTNF2
CALCA
CCDC196
CCHCR1
CCN3
CDC23
CDCA7L
CDR2L
CEP44
COG4
DEPTOR
FAM136A
FAM221B
FOLR3
FTO
GOLGA2
GOLGA6L9
GRIPAP1
HAUS3
HDAC3
HDAC4
HDAC5
HOMEZ
HOOK2
HRAS
IGFBP6
IKZF1
ITGB3BP
KANK2
KPNA3
KPNA6
KRT34
LZTS2
MKRN3
MTFR1L
MTUS2
MXRA8
MYF5
NAB2
NCOA1
NCOA2
NCOA3
NOTO
NTAQ1
PDE4DIP
PIH1D2
PLAGL2
PPARA
RAC3
RCOR3
RINT1
RPH3AL
RSPO4
RUBCN
SERTAD3
SNRNP35
SPANXN2
SPATA2
SPRY1
SRC
STMN3
STRA8
SYTL3
TADA2B
TFIP11
TLE5
TNNI1
TRAF2
TRIM37
TRIM54
TSPOAP1
TTC23L
TXN
UFC1
USH1G
USP54
USP6
VDR
ZNF426
ZNF552
ZNF655
ZNF688
ZRANB1
61 interacting genes:
ANKRA2
ANKRD11
ATF3
BCL6
BCOR
BRMS1
CAMK1
CAMTA2
CBX5
CIITA
CTBP1
DDX20
DYRK1B
EEF1G
ESR1
GABARAP
GATA1
GATA2
GCM1
GNB1
H3C1
HDAC3
HDAC7
HIF1A
HOXC11
HR
JDP2
KLF4
LMO2
MAFF
MEF2A
MEF2C
MEF2D
NCOR1
NCOR2
NFATC1
NFKB2
NFKBIE
NRIP1
PHB2
PKN1
PKN2
PRKAA1
PRKCD
PRKD1
RFXANK
RUNX3
SFN
SIK1
SIK2
SIK3
SLC2A4RG
SMAD3
SUV39H1
TAB2
UBC
UBE2I
YWHAB
YWHAE
YWHAQ
ZBTB16
Entrez ID
29123
10014
HPRD ID
12456
09246
Ensembl ID
ENSG00000167522
ENSG00000108840
Uniprot IDs
Q6UB99
Q9UQL6
PDB IDs
5UWI
Enriched GO Terms of Interacting Partners
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