IFI27 and APOC4

Data Source:
BioGRID (two hybrid)

		IFI27	APOC4
Description		interferon alpha inducible protein 27	apolipoprotein C4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Molecular_function Protein Binding Lamin Binding Identical Protein Binding	Lipid Transporter Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Viral Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral Genome Replication Innate Immune Response Regulation Of Protein Export From Nucleus Defense Response To Virus Type I Interferon Signaling Pathway Protein K48-linked Ubiquitination Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway	Lipid Metabolic Process Lipid Transport Positive Regulation Of Sequestering Of Triglyceride Very-low-density Lipoprotein Particle Assembly Very-low-density Lipoprotein Particle Clearance Triglyceride Homeostasis
Pathways		Interferon alpha/beta signaling	VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS			Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193043 18193044 20864672 19060906) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		4 interacting genes: APOC2 APOC4 CCND1 CDK4	24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1
Entrez ID		3429	346
HPRD ID		02479	02848
Ensembl ID		ENSG00000165949	ENSG00000267467
Uniprot IDs		P40305	P55056
PDB IDs
Enriched GO Terms of Interacting Partners?
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