PEX5 and ACOT4

Data Source:
BioGRID (unspecified method)

		PEX5	ACOT4
Description		peroxisomal biogenesis factor 5	acyl-CoA thioesterase 4
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GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding Protein Sequestering Activity	Succinyl-CoA Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Glutaryl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Protein Import Into Peroxisome Membrane	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Succinyl-CoA Metabolic Process Protein Targeting To Peroxisome Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Butyrate Metabolic Process Saturated Monocarboxylic Acid Metabolic Process Unsaturated Monocarboxylic Acid Metabolic Process Dicarboxylic Acid Metabolic Process Dicarboxylic Acid Catabolic Process Short-chain Fatty Acid Metabolic Process
Pathways		Pexophagy	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917) Refractive error ( 32231278)	Hippocampal volume ( 25625606) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		76 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 GDPD5 GLMN GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HNRNPH1 HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 PSAP RPL14 S100A6 SCARB1 SCP2 SCRN2 SIRT3 SLC27A2 SNUPN SSTR5 TIMMDC1 TINF2 TM6SF1 TOMM7 USP2 USP9X ZFAND3 ZNF772	1 interacting genes: PEX5
Entrez ID		5830	122970
HPRD ID		02684	17928
Ensembl ID		ENSG00000139197	ENSG00000177465
Uniprot IDs		A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542	Q8N9L9
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO	3K2I
Enriched GO Terms of Interacting Partners?
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