TSPAN33 and GAD2

Data Source:
BioGRID (two hybrid)

		TSPAN33	GAD2
Description		tetraspanin 33	glutamate decarboxylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Cell Surface Pore Complex Tetraspanin-enriched Microdomain	Golgi Membrane Cytosol Plasma Membrane Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Protein Binding Enzyme Binding	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding
	Biological Process	Cellular Protein Metabolic Process Pore Complex Assembly Protein Maturation Protein Localization To Plasma Membrane	Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug
Pathways		Amyloid fiber formation	GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 23128233)	Lean body mass ( 28552196)
Interacting Genes		27 interacting genes: CHRM2 CISD2 CLDN7 COQ9 DARS2 ERGIC3 FAM209A GAD2 GJA8 GORAB GPR152 GPX8 KCNK5 LHFPL5 LMNA MFF MGST3 MTIF3 NEMP1 PLEKHO1 RELL2 SHISA4 SIT1 SLC35C2 SPINT1 TMEM106C TMEM45B	45 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BSND CACNG1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A GAD1 HIGD1C LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TMEM159 TNFRSF10D TSPAN33
Entrez ID		340348	2572
HPRD ID		14669	11817
Ensembl ID		ENSG00000158457	ENSG00000136750
Uniprot IDs		Q86UF1	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK
Enriched GO Terms of Interacting Partners?
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