KRTAP6-3 and CAMK2B

Data Source:
BioGRID (two hybrid)

		KRTAP6-3	CAMK2B
Description		keratin associated protein 6-3	calcium/calmodulin dependent protein kinase II beta
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse
	Molecular Function		Actin Binding Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Keratinization	Protein Phosphorylation Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Regulation Of Neuron Migration
Pathways			CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Fostamatinib
Diseases
GWAS			Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549)
Interacting Genes		159 interacting genes: ADAMTSL4 AGXT ARID5A ARMC7 ATPAF2 AUTS2 BAG4 BEX2 BSCL2 C11orf87 CAMK2A CAMK2B CAMK2G CARHSP1 CCDC120 CCDC24 CCER1 CELF5 CHRD CLCNKA CNNM3 COL8A1 CREB5 CRY2 CTSZ CYSRT1 DALRD3 DHRS1 DMRT3 FADS6 FAM214B FAM83A FBXW5 FCHO1 FOXD2 FOXD4L1 GATA2 GATA3 GLYCTK GNE GPS2 HAPLN2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HR HYAL2 ILF2 INCA1 INPP5D ITGB4 KANK2 KPRP KRT20 KRTAP11-1 KRTAP12-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP4-4 KRTAP6-1 KRTAP6-2 LAGE3 LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3C LCE3D LCE3E LCE5A LGALS9 LNX1 MAGED1 MAPK1IP1L MAPKBP1 MBD3L2 MED25 MEIS2 MEOX2 MGAT5B NODAL NOTO NR4A3 OLIG3 OTX1 OXER1 P4HB PATZ1 PCDHB14 PGAP6 PHETA1 PHLDA1 PIGS PITX1 PLSCR4 POU4F2 POU4F3 PPP1R32 PPP1R37 PRMT8 PROP1 PRPF31 PRR13 PRR3 PRR35 PSMA1 PVR RAB3IL1 RAD54L2 RASD1 RHBDL1 RUNX1T1 SAMD7 SEMA4C SH3KBP1 SLC15A2 SLC22A5 SMARCC1 SMARCE1 SMCP SNRPB SNRPC SNX18 STK16 STRA6 TAOK2 TBX2 TBX6 TCAF1 TCF7L2 TEKT4 TENT2 TEX45 TFAP2D TLE5 TLX3 TNIP1 TNS2 TSPYL6 TYK2 VASN VENTX VSTM4 WDR25 ZBTB32 ZIC1 ZNF414 ZNF497 ZNF575 ZNF79	56 interacting genes: ACOT7 ACTN4 AP5B1 ARSA ATXN1 CAMK2A CAMK2D CAMK2G CAMK2N2 CCM2L CDC37 COL4A3 DUS1L ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRT86 KRTAP1-1 KRTAP10-11 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 MAD2L2 MED18 MEOX2 MGAT5B MORF4L1 MORF4L2 MRPL11 MVP PHKB PLCB3 PNKP POLR3C POP5 RAP2B RBFOX2 RBPMS RNF4 RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TNPO2 TNPO3 TTC5 YWHAB ZBTB32 ZMYM5
Entrez ID		337968	816
HPRD ID		11220	12127
Ensembl ID		ENSG00000212938	ENSG00000058404
Uniprot IDs			A4D2J9 B7Z1Z6 Q13554
PDB IDs			3BHH
Enriched GO Terms of Interacting Partners?
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