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KRTAP6-3 and NODAL
Data Source:
BioGRID
(two hybrid)
KRTAP6-3
NODAL
Description
keratin associated protein 6-3
nodal growth differentiation factor
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Intermediate Filament
Extracellular Space
Molecular Function
Cytokine Activity
Protein Binding
Growth Factor Activity
Morphogen Activity
Type I Activin Receptor Binding
Biological Process
Keratinization
Negative Regulation Of Transcription By RNA Polymerase II
Trophectodermal Cellular Morphogenesis
Neural Fold Formation
Liver Development
Placenta Development
Embryonic Placenta Development
Maternal Placenta Development
Vasculature Development
Heart Looping
Inhibition Of Neuroepithelial Cell Differentiation
Brain Development
Embryonic Pattern Specification
Polarity Specification Of Proximal/distal Axis
Regulation Of Gastrulation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Cell Development
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Stem Cell Population Maintenance
Positive Regulation Of Cell-cell Adhesion
BMP Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Floor Plate Morphogenesis
Endodermal Cell Differentiation
Cell Migration Involved In Gastrulation
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Axial Mesodermal Cell Fate Specification
Mesendoderm Development
Digestive Tract Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Formation Of Anatomical Boundary
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of DNA-binding Transcription Factor Activity
Embryonic Process Involved In Female Pregnancy
Maternal Process Involved In Parturition
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Left Lung Morphogenesis
Negative Regulation Of Androgen Receptor Signaling Pathway
Epiblast Cell-extraembryonic Ectoderm Cell Signaling Involved In Anterior/posterior Axis Specification
Positive Regulation Of ERK1 And ERK2 Cascade
Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Primitive Streak Formation
Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Negative Regulation Of Trophoblast Cell Migration
Negative Regulation Of Chorionic Trophoblast Cell Proliferation
Regulation Of Stem Cell Population Maintenance
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
Drugs
Diseases
Heterotaxy; Situs ambiguus
GWAS
Interacting Genes
159 interacting genes:
ADAMTSL4
AGXT
ARID5A
ARMC7
ATPAF2
AUTS2
BAG4
BEX2
BSCL2
C11orf87
CAMK2A
CAMK2B
CAMK2G
CARHSP1
CCDC120
CCDC24
CCER1
CELF5
CHRD
CLCNKA
CNNM3
COL8A1
CREB5
CRY2
CTSZ
CYSRT1
DALRD3
DHRS1
DMRT3
FADS6
FAM214B
FAM83A
FBXW5
FCHO1
FOXD2
FOXD4L1
GATA2
GATA3
GLYCTK
GNE
GPS2
HAPLN2
HHEX
HOXA1
HOXB5
HOXB9
HOXC8
HR
HYAL2
ILF2
INCA1
INPP5D
ITGB4
KANK2
KPRP
KRT20
KRTAP11-1
KRTAP12-2
KRTAP19-2
KRTAP19-5
KRTAP19-6
KRTAP19-7
KRTAP26-1
KRTAP4-4
KRTAP6-1
KRTAP6-2
LAGE3
LCE1B
LCE1C
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE3A
LCE3C
LCE3D
LCE3E
LCE5A
LGALS9
LNX1
MAGED1
MAPK1IP1L
MAPKBP1
MBD3L2
MED25
MEIS2
MEOX2
MGAT5B
NODAL
NOTO
NR4A3
OLIG3
OTX1
OXER1
P4HB
PATZ1
PCDHB14
PGAP6
PHETA1
PHLDA1
PIGS
PITX1
PLSCR4
POU4F2
POU4F3
PPP1R32
PPP1R37
PRMT8
PROP1
PRPF31
PRR13
PRR3
PRR35
PSMA1
PVR
RAB3IL1
RAD54L2
RASD1
RHBDL1
RUNX1T1
SAMD7
SEMA4C
SH3KBP1
SLC15A2
SLC22A5
SMARCC1
SMARCE1
SMCP
SNRPB
SNRPC
SNX18
STK16
STRA6
TAOK2
TBX2
TBX6
TCAF1
TCF7L2
TEKT4
TENT2
TEX45
TFAP2D
TLE5
TLX3
TNIP1
TNS2
TSPYL6
TYK2
VASN
VENTX
VSTM4
WDR25
ZBTB32
ZIC1
ZNF414
ZNF497
ZNF575
ZNF79
6 interacting genes:
ACVR1B
ACVR2A
ACVR2B
KRT31
KRTAP6-3
TDGF1
Entrez ID
337968
4838
HPRD ID
11220
08370
Ensembl ID
ENSG00000212938
ENSG00000156574
Uniprot IDs
Q96S42
PDB IDs
4N1D
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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