HTR4 and GGT7

Data Source:
BioGRID (two hybrid)

		HTR4	GGT7
Description		5-hydroxytryptamine receptor 4	gamma-glutamyltransferase 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Synapse	Plasma Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding	Peptidyltransferase Activity Protein Binding Glutathione Hydrolase Activity Hypoglycin A Gamma-glutamyl Transpeptidase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Appetite	Translation Proteolysis Glutathione Biosynthetic Process Glutathione Catabolic Process Spermatogenesis Protein Phosphopantetheinylation Response To Estradiol Response To Lipopolysaccharide Response To Tumor Necrosis Factor Leukotriene D4 Biosynthetic Process Negative Regulation Of Response To Oxidative Stress
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Glutathione synthesis and recycling Aflatoxin activation and detoxification
Drugs		Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)	Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate ( 31451708) Fish- and plant-related diet ( 32066663) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7	13 interacting genes: CLDN19 CMTM7 CYB561 GPR25 HTR4 LHFPL5 LNPEP MALL MTNR1B SLC35A4 TLCD3A TMEM242 TSPO2
Entrez ID		3360	2686
HPRD ID		09074	07488
Ensembl ID		ENSG00000164270	ENSG00000131067
Uniprot IDs		A0A2D3FAF9 Q13639	A0PJJ9 Q9UJ14
PDB IDs		5EM9
Enriched GO Terms of Interacting Partners?
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