GGT7 and HTR4

Data Source:
BioGRID (two hybrid)

		GGT7	HTR4
Description		gamma-glutamyltransferase 7	5-hydroxytryptamine receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Peptidyltransferase Activity Protein Binding Glutathione Hydrolase Activity Hypoglycin A Gamma-glutamyl Transpeptidase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding
	Biological Process	Translation Proteolysis Glutathione Biosynthetic Process Glutathione Catabolic Process Spermatogenesis Protein Phosphopantetheinylation Response To Estradiol Response To Lipopolysaccharide Response To Tumor Necrosis Factor Leukotriene D4 Biosynthetic Process Negative Regulation Of Response To Oxidative Stress	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Appetite
Pathways		Glutathione synthesis and recycling Aflatoxin activation and detoxification	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases
GWAS		Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate ( 31451708) Fish- and plant-related diet ( 32066663) Reticulocyte fraction of red cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)
Interacting Genes		13 interacting genes: CLDN19 CMTM7 CYB561 GPR25 HTR4 LHFPL5 LNPEP MALL MTNR1B SLC35A4 TLCD3A TMEM242 TSPO2	18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7
Entrez ID		2686	3360
HPRD ID		07488	09074
Ensembl ID		ENSG00000131067	ENSG00000164270
Uniprot IDs		A0PJJ9 Q9UJ14	A0A2D3FAF9 Q13639
PDB IDs			5EM9
Enriched GO Terms of Interacting Partners?
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