HTR4 and ANO10

Data Source:
BioGRID (two hybrid)

		HTR4	ANO10
Description		5-hydroxytryptamine receptor 4	anoctamin 10
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GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Synapse	Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding	Calcium Activated Cation Channel Activity Intracellular Calcium Activated Chloride Channel Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Appetite	Cation Transport Chloride Transport Ion Transmembrane Transport Transmembrane Transport Cation Transmembrane Transport Chloride Transmembrane Transport
Pathways		Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Stimuli-sensing channels
Drugs		Cisapride Paroxetine Ondansetron Ergoloid mesylate Tegaserod Metoclopramide Chlorprothixene Piboserod Renzapride Naronapride TD-2749 Ticalopride Prucalopride Cinitapride Setiptiline Dihydroergocornine Gilteritinib Velusetrag Tiapride Dihydroergocristine
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Airflow obstruction ( 22837378) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) FEV1 ( 30804560) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Peak expiratory flow ( 30804560) Periodontal microbiota ( 22699663) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30578418) Urinary sodium excretion ( 31409800)	Gastroesophageal reflux disease ( 31527586) Obesity-related traits ( 23251661) Primary central nervous system lymphoma ( 31102405)
Interacting Genes		18 interacting genes: ADRB2 ANO10 CD81 CERS1 CLDN10 CLTB ELOVL5 GDF1 GGT7 GHITM GPR37 GPRIN2 MGLL SARAF SLC39A1 TMEFF2 TMEM230 TSPAN7	1 interacting genes: HTR4
Entrez ID		3360	55129
HPRD ID		09074	07667
Ensembl ID		ENSG00000164270	ENSG00000160746
Uniprot IDs		A0A2D3FAF9 Q13639	A0A024R2S0 Q9NW15
PDB IDs		5EM9	5OC9 6R65 6R7X 6R7Y 6R7Z
Enriched GO Terms of Interacting Partners?
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