HSBP1 and MPHOSPH6

Data Source:
HPRD (in vitro)

		HSBP1	MPHOSPH6
Description		heat shock factor binding protein 1	M-phase phosphoprotein 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cytoskeleton	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Endodermal Cell Differentiation Cellular Heat Acclimation Regulation Of Cellular Response To Heat	Maturation Of 5.8S RRNA RRNA Processing
Pathways		HSF1 activation Attenuation phase HSF1-dependent transactivation	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Lead levels ( 26025379) Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)	Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)
Interacting Genes		21 interacting genes: BLOC1S5 BRK1 CCHCR1 CYSRT1 GORASP2 HSF1 HSPA1A KIAA1217 KIFC3 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 LNX1 MPP7 NOTCH2NLA SDCBP SDCBP2 WASHC1 WASHC3 ZBTB25	32 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		3281	10200
HPRD ID		05185	16111
Ensembl ID		ENSG00000230989	ENSG00000135698
Uniprot IDs		O75506	H3BNT4 Q99547
PDB IDs		3CI9	6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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