AIRE and UBAC1

Data Source:
BioGRID (two hybrid)

		AIRE	UBAC1
Description		autoimmune regulator	UBA domain containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Body	Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Translation Regulator Activity	Protein Binding
	Biological Process	Peripheral T Cell Tolerance Induction Central Tolerance Induction To Self Antigen Regulation Of Transcription, DNA-templated Regulation Of Translation Immune Response Humoral Immune Response Chemokine Production Negative Thymic T Cell Selection Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Thymus Epithelium Morphogenesis Regulation Of Thymocyte Migration	Protein Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Rheumatoid arthritis ( 21505073 30423114)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: CREBBP DAXX H2BC21 H3C1 UBAC1	34 interacting genes: AIRE APP ARRDC3 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBB UBC UBQLN2 ZDHHC17 ZG16B
Entrez ID		326	10422
HPRD ID		06301	12170
Ensembl ID		ENSG00000160224	ENSG00000130560
Uniprot IDs		O43918	A0A140VK64 Q9BSL1
PDB IDs		1XWH 2KE1 2KFT 2LRI	2DAI
Enriched GO Terms of Interacting Partners?
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