UBAC1 and AIRE

Data Source:
BioGRID (two hybrid)

		UBAC1	AIRE
Description		UBA domain containing 1	autoimmune regulator
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GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome	Nucleus Cytoplasm Nuclear Body
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Translation Regulator Activity
	Biological Process	Protein Ubiquitination	Peripheral T Cell Tolerance Induction Central Tolerance Induction To Self Antigen Regulation Of Transcription, DNA-templated Regulation Of Translation Immune Response Humoral Immune Response Chemokine Production Negative Thymic T Cell Selection Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Thymus Epithelium Morphogenesis Regulation Of Thymocyte Migration
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)	Dental caries (decayed, missing and filled teeth) ( 31533690) Rheumatoid arthritis ( 21505073 30423114)
Interacting Genes		34 interacting genes: AIRE APP ARRDC3 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBB UBC UBQLN2 ZDHHC17 ZG16B	5 interacting genes: CREBBP DAXX H2BC21 H3C1 UBAC1
Entrez ID		10422	326
HPRD ID		12170	06301
Ensembl ID		ENSG00000130560	ENSG00000160224
Uniprot IDs		A0A140VK64 Q9BSL1	O43918
PDB IDs		2DAI	1XWH 2KE1 2KFT 2LRI
Enriched GO Terms of Interacting Partners?
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