HMGN2 and RPS6KA3

Data Source:
HPRD (in vitro)

		HMGN2	RPS6KA3
Description		high mobility group nucleosomal binding domain 2	ribosomal protein S6 kinase A3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Space Nucleus Cytoplasm	Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Chromatin Binding RNA Binding Protein Binding Nucleosomal DNA Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Chromatin Organization Killing Of Cells Of Other Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Skeletal System Development Toll-like Receptor Signaling Pathway Apoptotic Process Cell Cycle Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Acetylsalicylic acid Fostamatinib
Diseases			Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		Rosacea symptom severity ( 29771307)	Refractive error ( 32231278)
Interacting Genes		13 interacting genes: EP300 HMGN1 HPF1 KAT2B MTNR1A PARP1 PRKACA PRKCA RPS6KA3 SRPK2 TERF2 UBC UBE2I	40 interacting genes: ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR1 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS SRC STK11 SUMO2 TP53 YBX1
Entrez ID		3151	6197
HPRD ID		01230	02092
Ensembl ID		ENSG00000198830	ENSG00000177189
Uniprot IDs		P05204	A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812
PDB IDs			4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L
Enriched GO Terms of Interacting Partners?
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