EZH2 and PHF1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		EZH2	PHF1
Description		enhancer of zeste 2 polycomb repressive complex 2 subunit	PHD finger protein 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Cytoplasm ESC/E(Z) Complex Pronucleus	Nucleus Nucleoplasm Cytoplasm Centrosome ESC/E(Z) Complex Site Of Double-strand Break
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H3-K27 Specific) Primary MiRNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding Identical Protein Binding Metal Ion Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Organization Chromatin Silencing At Telomere Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cardiac Muscle Hypertrophy In Response To Stress Histone Methylation Cerebellar Cortex Development Hippocampus Development B Cell Differentiation Response To Estradiol Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Trichostatin A Hepatocyte Homeostasis Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of GTPase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Cell Development Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Liver Regeneration Histone H3-K27 Trimethylation Positive Regulation Of Dendrite Development Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Tetrachloromethane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Organization Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	PRC2 methylates histones and DNA
Drugs		Tazemetostat CPI-1205
Diseases
GWAS		Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Height ( 25282103 31562340) Inflammatory bowel disease ( 28067908) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Refractive error ( 32231278)
Interacting Genes		77 interacting genes: AKT1 AR ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK2 CDK6 CDKN2B-AS1 CEP63 CRY2 DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H3-4 H3C1 HDAC1 HOTAIR JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 MYCN NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 USP1 VAV1 WDR61 WSB2 ZMYND11	77 interacting genes: ABI2 ARID5A ARRDC3 ATXN7L1 AVPI1 BHLHB9 BHLHE40 BIRC7 BOLL C11orf49 CALCOCO2 DISC1 DPF1 DYSF EFHC2 EZH2 FHL2 FOSB GOLGA6L9 GPKOW H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HOMEZ HSD17B14 INCA1 IRAK1BP1 KIAA0408 KRT40 LBX1 LZTS2 MAGED1 MDFI MEOX2 MORN3 NAB2 NEK6 PATZ1 PDLIM7 PFDN5 PIBF1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8NL RBPMS SMG9 SORBS3 SPAG8 TFCP2 TFIP11 THAP1 TLE5 TNS2 TOX2 TP53BP2 TRIM23 USP54 VAC14 ZBTB10 ZBTB16 ZIM2 ZNF500 ZNF526 ZNF688 ZNF71 ZRANB1 ZSCAN32
Entrez ID		2146	5252
HPRD ID		03342	04195
Ensembl ID		ENSG00000106462	ENSG00000112511
Uniprot IDs		A0A090N8E9 Q15910 S4S3R8	A0A140VJR4 A0A1U9X8A3 O43189
PDB IDs		2C6V 4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6P5L 6U4Y	2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP 6WAT 6WAV
Enriched GO Terms of Interacting Partners?
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