HCCS and SENP2

Data Source:
BioGRID (two hybrid)

		HCCS	SENP2
Description		holocytochrome c synthase	SUMO specific peptidase 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	Nucleus Nuclear Pore Nucleoplasm Cytosol PML Body Nuclear Membrane
	Molecular Function	Holocytochrome-c Synthase Activity Protein Binding Heme Binding Metal Ion Binding	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding SUMO-specific Endopeptidase Activity SUMO-specific Isopeptidase Activity
	Biological Process	Animal Organ Morphogenesis Cytochrome C-heme Linkage Protein Phosphopantetheinylation	Positive Regulation Of Protein Phosphorylation Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			SUMO is proteolytically processed
Drugs
Diseases		Anophthalmia and microphthalmia (A/M)
GWAS		Cognitive performance ( 19734545)	Diastolic blood pressure ( 28135244 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 27841878 26969751)
Interacting Genes		3 interacting genes: CIDEB SENP2 SNX1	38 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63
Entrez ID		3052	59343
HPRD ID		02085	07002
Ensembl ID		ENSG00000004961	ENSG00000163904
Uniprot IDs		A0A024RBY9 P53701	Q9HC62
PDB IDs			1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK
Enriched GO Terms of Interacting Partners?
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