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STAP1 and GAB1
Data Source:
BioGRID
(pull down)
STAP1
GAB1
Description
signal transducing adaptor family member 1
GRB2 associated binding protein 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Cytosol
Cell-cell Junction
Molecular Function
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Macrophage Colony-stimulating Factor Receptor Binding
Protein Binding
Phospholipid Binding
Protein Kinase Binding
Signaling Adaptor Activity
Protein Binding
Biological Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Macrophage Chemotaxis
Negative Regulation Of Phosphorylation
Positive Regulation Of B Cell Receptor Signaling Pathway
Positive Regulation Of Phagocytosis, Engulfment
Cellular Response To Lipopolysaccharide
Negative Regulation Of Ruffle Assembly
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Positive Regulation Of Microglial Cell Activation
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Negative Regulation Of Microglial Cell Migration
Positive Regulation Of Microglial Cell Mediated Cytotoxicity
Positive Regulation Of Actin Cytoskeleton Reorganization
Angiogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Insulin Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Actin Cytoskeleton Reorganization
Response To Hepatocyte Growth Factor
Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway
ERBB2 Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase B Signaling
Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor
Pathways
PI3K Cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PIP3 activates AKT signaling
GAB1 signalosome
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
MET activates PTPN11
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Drugs
Diseases
GWAS
Regular attendance at a pub or social club (
29970889
)
Asthma (
21804548
)
Diastolic blood pressure (
27841878
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Height (
31562340
)
Malaria (
31844061
)
Systolic blood pressure (
27841878
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Interacting Genes
14 interacting genes:
AR
EGFR
ERBB2
ERBB3
ERBB4
GAB1
GRIPAP1
KIT
MET
PTK2B
RETREG3
SH3KBP1
TEC
URI1
73 interacting genes:
ARHGAP32
BCAR3
BLK
BLNK
BTK
C1QBP
CRK
CRKL
EGFR
EPOR
ERBB2
FCGR2B
FES
FRS2
GAB2
GRAP2
GRB2
GTF2A1L
HCK
HSH2D
INPP5D
INPPL1
INSR
ITK
JAK1
LAT2
LCK
LYN
MAP3K3
MAPK1
MAPK3
MAPK4
MARK2
MET
MST1R
NCK1
NCK2
PDGFRB
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PTK6
PTPN11
PTPN18
RASA1
RET
SH2D1B
SH2D2A
SH2D3A
SHC1
SHC3
SLA
SLA2
SOCS3
SOCS6
SOS1
SRC
STAP1
SUPT6H
SYK
SYP
TEC
TNS1
TNS3
TNS4
TRIM15
VAV1
VAV2
VAV3
YES1
Entrez ID
26228
2549
HPRD ID
16053
05116
Ensembl ID
ENSG00000035720
ENSG00000109458
Uniprot IDs
A0A024RD91
Q9ULZ2
Q13480
Q9HA84
PDB IDs
1X1F
3MAZ
4QSY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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