STAP1 and URI1

Data Source:
HPRD (in vivo, in vitro)

		STAP1	URI1
Description		signal transducing adaptor family member 1	URI1 prefoldin like chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Protein-containing Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Dendrite
	Molecular Function	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Signaling Adaptor Activity	RNA Polymerase II Complex Binding Chromatin Binding Transcription Corepressor Activity Protein Phosphatase Inhibitor Activity Protein Binding Phosphatase Inhibitor Activity Phosphoprotein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Phosphorylation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Cellular Response To Lipopolysaccharide Negative Regulation Of Ruffle Assembly Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Activation Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Microglial Cell Migration Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Actin Cytoskeleton Reorganization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of Transcription By RNA Polymerase II Response To Virus Negative Regulation Of Phosphatase Activity Negative Regulation Of Phosphoprotein Phosphatase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Body mass index ( 26426971) Cerebrospinal P-tau181p levels ( 28247064) Diastolic blood pressure ( 27841878) Serum urate levels in chronic kidney disease ( 30181573)
Interacting Genes		14 interacting genes: AR EGFR ERBB2 ERBB3 ERBB4 GAB1 GRIPAP1 KIT MET PTK2B RETREG3 SH3KBP1 TEC URI1	10 interacting genes: APP ATF7 CIAO1 DMAP1 GTF2F2 ITCH NEDD4 POLR2E RPS6KB1 STAP1
Entrez ID		26228	8725
HPRD ID		16053	11943
Ensembl ID		ENSG00000035720	ENSG00000105176
Uniprot IDs		A0A024RD91 Q9ULZ2	O94763
PDB IDs		1X1F 3MAZ
Enriched GO Terms of Interacting Partners?
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