ACAA1 and HAT1

Data Source:
BioGRID (enzymatic study)

		ACAA1	HAT1
Description		acetyl-CoA acyltransferase 1	histone acetyltransferase 1
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GO Annotations	Cellular Component	Extracellular Region Peroxisome Peroxisomal Matrix Cytosol Membrane Specific Granule Lumen	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Protein-containing Complex
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA C-acyltransferase Activity Protein Binding Acetate CoA-transferase Activity Palmitoyl-CoA Oxidase Activity Acetyl-CoA C-myristoyltransferase Activity	Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity Histone Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Bile Acid Metabolic Process Phenylacetate Catabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Neutrophil Degranulation	DNA Packaging DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Silencing At Telomere Internal Protein Amino Acid Acetylation Response To Nutrient Histone H4 Acetylation
Pathways		alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	HATs acetylate histones
Drugs		Trimetazidine
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		4 interacting genes: FEM1A HAT1 TFCP2 TXNDC11	23 interacting genes: ACAA1 H2AC20 H3-4 H3C1 H4-16 H4C1 H4C14 HTR2B KANK4 MEOX2 MORN5 PRKAA2 RBBP4 REL SMAD7 SNAPC1 STEEP1 TCF4 TEPSIN TNFAIP1 TRIB3 YWHAQ ZSCAN4
Entrez ID		30	8520
HPRD ID		06815	04339
Ensembl ID		ENSG00000060971	ENSG00000128708
Uniprot IDs		A0A024R2M6 A0A140VJX0 P09110	O14929
PDB IDs		2IIK	2P0W 6VO5
Enriched GO Terms of Interacting Partners?
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