TRPV4 and MAP7

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TRPV4	MAP7
Description		transient receptor potential cation channel subfamily V member 4	microtubule associated protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Focal Adhesion Cilium Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane	Cytosol Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Basolateral Plasma Membrane Axon Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Kinase C Binding Ion Channel Activity Cation Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Microtubule Binding Lipid Binding Stretch-activated, Cation-selective, Calcium Channel Activity Protein Kinase Binding SH2 Domain Binding Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding Actin Filament Binding	Signaling Receptor Binding Structural Molecule Activity Protein Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Cell Volume Homeostasis Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Negative Regulation Of Neuron Projection Development Positive Regulation Of Microtubule Depolymerization Actin Cytoskeleton Reorganization Cellular Response To Heat Positive Regulation Of Vascular Permeability Cortical Microtubule Organization Microtubule Polymerization Multicellular Organismal Water Homeostasis Cartilage Development Involved In Endochondral Bone Morphogenesis Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response Blood Vessel Endothelial Cell Delamination Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol	Microtubule Cytoskeleton Organization Response To Osmotic Stress Establishment Or Maintenance Of Cell Polarity Protein Localization To Plasma Membrane
Pathways		TRP channels
Drugs		Cannabidiol Butamben Medical Cannabis Nabiximols
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC) Distal hereditary motor neuropathies (dHMN)
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010)	Cerebrospinal fluid sTREM-2 levels ( 31708768) Pursuit maintenance gain ( 29064472)
Interacting Genes		14 interacting genes: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1	8 interacting genes: CCDC70 CLIP4 CLK1 POT1 SRPK2 TERF1 TRPV4 ZNF114
Entrez ID		59341	9053
HPRD ID		05667	04982
Ensembl ID		ENSG00000111199	ENSG00000135525
Uniprot IDs		Q9HBA0	A0A087WZ40 B7Z3E1 B7Z3Y3 B7ZB64 Q14244
PDB IDs		4DX1 4DX2
Enriched GO Terms of Interacting Partners?
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