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GSK3B and NOTCH2
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HPRD
(in vitro, in vivo)
GSK3B
NOTCH2
Description
glycogen synthase kinase 3 beta
notch receptor 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Plasma Membrane
Axon
Dendrite
Beta-catenin Destruction Complex
Postsynapse
Glutamatergic Synapse
Wnt Signalosome
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Cilium
Cell Surface
Membrane
Receptor Complex
Molecular Function
RNA Polymerase II Transcription Factor Binding
Protease Binding
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Beta-catenin Binding
Kinase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Dynactin Binding
Tau Protein Binding
Tau-protein Kinase Activity
NF-kappaB Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Calcium Ion Binding
Protein Binding
Enzyme Binding
Signaling Receptor Activity
NF-kappaB Binding
Biological Process
Epithelial To Mesenchymal Transition
Positive Regulation Of Cell-matrix Adhesion
Glycogen Metabolic Process
Protein Phosphorylation
ER Overload Response
Signal Transduction
Dopamine Receptor Signaling Pathway
Circadian Rhythm
Insulin Receptor Signaling Pathway
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Positive Regulation Of Mitochondrion Organization
Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Hippocampus Development
Establishment Of Cell Polarity
Maintenance Of Cell Polarity
Regulation Of Axon Extension
Neuron Projection Development
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Phosphoprotein Phosphatase Activity
Regulation Of Microtubule-based Process
Intracellular Signal Transduction
Cellular Response To Interleukin-3
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Protein Autophosphorylation
Positive Regulation Of Protein Export From Nucleus
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Excitatory Postsynaptic Potential
Regulation Of Microtubule Cytoskeleton Organization
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Superior Temporal Gyrus Development
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Neuron Projection Organization
Regulation Of Microtubule Anchoring At Centrosome
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Neuron Death
Positive Regulation Of Neuron Death
Negative Regulation Of Protein Acetylation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Dopaminergic Neuron Differentiation
Cellular Response To Amyloid-beta
Positive Regulation Of Protein Localization To Centrosome
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Negative Regulation Of Type B Pancreatic Cell Development
Regulation Of Synaptic Vesicle Exocytosis
Negative Regulation Of Glycogen (starch) Synthase Activity
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Heart Looping
Morphogenesis Of An Epithelial Sheet
Marginal Zone B Cell Differentiation
Inflammatory Response To Antigenic Stimulus
Pulmonary Valve Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Humoral Immune Response
Cell Cycle Arrest
Notch Signaling Pathway
Multicellular Organism Development
Nervous System Development
Axon Guidance
Animal Organ Morphogenesis
Negative Regulation Of Gene Expression
Positive Regulation Of Keratinocyte Proliferation
Stem Cell Population Maintenance
Hemopoiesis
Embryonic Limb Morphogenesis
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intrahepatic Bile Duct Development
Wound Healing
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Growth Rate
Positive Regulation Of Ras Protein Signal Transduction
Bone Remodeling
Atrial Septum Morphogenesis
Placenta Blood Vessel Development
Ciliary Body Morphogenesis
Notch Signaling Involved In Heart Development
Positive Regulation Of ERK1 And ERK2 Cascade
Left/right Axis Specification
Proximal Tubule Development
Glomerular Visceral Epithelial Cell Development
Glomerular Capillary Formation
Hepatocyte Proliferation
Cholangiocyte Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Osteoclast Development
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
B-WICH complex positively regulates rRNA expression
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Constitutive Signaling by AKT1 E17K in Cancer
Ubiquitin-dependent degradation of Cyclin D
Regulation of RUNX2 expression and activity
Replication of the SARS-CoV-1 genome
Maturation of nucleoprotein
Maturation of nucleoprotein
Maturation of nucleoprotein
Replication of the SARS-CoV-2 genome
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in Golgi
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 Activation and Transmission of Signal to the Nucleus
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Lithium cation
3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
SB-409513
AR-AO-14418
Staurosporine
Indirubin-3'-monoxime
6-bromoindirubin-3'-oxime
Alsterpaullone
Phosphoaminophosphonic Acid-Adenylate Ester
2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Fostamatinib
Tideglusib
Lithium citrate
Lithium succinate
Lithium carbonate
Diseases
Alagille syndrome
Type II diabetes mellitus
Hajdu-Cheney syndrome
GWAS
HDL cholesterol (
24097068
)
HDL cholesterol levels (
28334899
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Low density lipoprotein cholesterol levels (
32154731
)
Neutrophil count (
32888494
)
Platelet distribution width (
32888494
)
Blood protein levels (
30072576
)
Hepatocyte growth factor levels (
25998175
)
Nevus count or cutaneous melanoma (
32341527
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
18372903
30054458
30297969
)
Interacting Genes
225 interacting genes:
ACLY
ACSBG1
ACTL6B
ADAP1
ADIRF
AKAP11
AKT1
AKT2
AKT3
APC
APP
AR
ARRB1
ASRGL1
ATP5IF1
ATXN3
AURKA
AXIN1
AXIN2
BAG6
BCL2A1
BCL2L1
BCL3
BEX1
BHLHE41
BICD1
BICD2
BRIX1
BTRC
BZW2
CABYR
CAMSAP3
CCND1
CCNE1
CDH1
CDK5
CDX2
CEBPA
CEBPD
CEBPZ
CENPB
CHD3
CIITA
CLEC3B
CREB1
CREB3L3
CREM
CSAD
CSNK2B
CST6
CTNNB1
CTNND1
DBI
DCTN1
DCTN2
DCTN3
DDIT4
DEAF1
DEFA1
DELEC1
DHX34
DISC1
DNAJC13
DNM1L
DNMT1
DNMT3L
DPYSL2
DUSP9
DYNC1I1
E2F1
EEF1G
EFTUD2
EIF2B5
EIF4EBP1
ENTPD6
ERG28
EYA1
FAM193B
FAM83D
FBN3
FBXO7
FBXW11
FEN1
FIBP
FKBP14
FOXO1
FRAT1
FRAT2
FZD5
GBP2
GFI1
GIPC1
GJB5
GNB2
GPR39
GYS1
HDAC4
HNRNPD
HSP90AA1
HSPA4
IGHM
IGSF21
IKBKG
ILK
IQCG
IRF1
JUN
KDM1A
KHSRP
KIAA1191
KIF5B
KLF2
KLF5
LMO4
LPCAT1
LRP6
LUC7L2
MAP1B
MAP3K1
MAP3K4
MAP4
MAPK1
MAPT
MARK2
MASP1
MCL1
MDM2
MED24
MICAL1
MID1IP1
MITF
MPP1
MTF2
MTOR
MUC1
MYC
MYOCD
NAT9
NBR1
NCOA3
NDRG1
NFE2L1
NFE2L2
NFE2L3
NFKB1
NIN
NOTCH1
NOTCH2
NRBP1
NSFL1C
OGA
OGT
PDE4D
PFKFB4
PHLPP1
PIAS1
PIM2
PMAIP1
PPARGC1A
PPP1R2
PRKACA
PRKCA
PRKCB
PRKCZ
PRKDC
PSEN1
PTK2
PTN
PTPN1
PXN
QARS1
RAI1
RBPJ
RCAN1
RELB
RICTOR
RPL36AL
RPLP1
RPS2
RPS6KA1
RSU1
RXRA
SAP30BP
SGK1
SGK3
SLA
SMAD3
SNAI1
SNCA
SNCAIP
SOX10
SPTBN4
SREBF1
STAT2
SYNE4
TAZ
TLE1
TMEM132A
TMEM44
TNFAIP3
TONSL
TP53
TPPP
TRAF6
TSC2
TUBA1A
UBE2D1
UBR1
UBR5
UBXN6
UFM1
UPF3A
VIM
VPS51
WSB1
XIAP
XPNPEP1
YBX1
YBX3
YWHAZ
ZFPM1
ZHX1
ZNF135
ZNF227
ZNF746
31 interacting genes:
ANKRD28
CCR2
CNTN1
CRKL
CST6
DLL1
DTX1
DTX3
EGFL7
EPSTI1
GSK3B
IL13RA2
IL24
ITIH5
JAG1
JAG2
KLK5
LFNG
LRATD2
MAML1
MAML2
MAML3
MFNG
MTA3
MYOC
PSEN1
PSEN2
PSMC3IP
RBPJ
SMAD1
ST14
Entrez ID
2932
4853
HPRD ID
05418
02606
Ensembl ID
ENSG00000082701
ENSG00000134250
Uniprot IDs
P49841
Q6FI27
Q04721
Q6IQ50
Q9UFD5
PDB IDs
1GNG
1H8F
1I09
1J1B
1J1C
1O6K
1O6L
1O9U
1PYX
1Q3D
1Q3W
1Q41
1Q4L
1Q5K
1R0E
1UV5
2JDO
2JDR
2JLD
2O5K
2OW3
2UW9
2X39
2XH5
3CQU
3CQW
3DU8
3E87
3E88
3E8D
3F7Z
3F88
3GB2
3I4B
3L1S
3M1S
3MV5
3OW4
3PUP
3Q3B
3QKK
3SAY
3SD0
3ZDI
3ZRK
3ZRL
3ZRM
4ACC
4ACD
4ACG
4ACH
4AFJ
4B7T
4DIT
4EKK
4IQ6
4J1R
4J71
4NM0
4NM3
4NM5
4NM7
4PTC
4PTE
4PTG
5F94
5F95
5HLN
5HLP
5K5N
5KPK
5KPL
5KPM
5OY4
5T31
6B8J
6BUU
6GJO
6GN1
6H0U
6HK3
6HK4
6HK7
6NPZ
6TCU
6V6L
6Y9R
6Y9S
2OO4
5MWB
Enriched GO Terms of Interacting Partners
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