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GSK3B and CTNNB1
Data Source:
HPRD
(in vitro, in vivo)
GSK3B
CTNNB1
Description
glycogen synthase kinase 3 beta
catenin beta 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Centrosome
Cytosol
Plasma Membrane
Axon
Dendrite
Beta-catenin Destruction Complex
Postsynapse
Glutamatergic Synapse
Wnt Signalosome
Euchromatin
Spindle Pole
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Focal Adhesion
Cell Cortex
Membrane
Basolateral Plasma Membrane
Lateral Plasma Membrane
Catenin Complex
Cell Junction
Beta-catenin Destruction Complex
Protein-containing Complex
Protein-DNA Complex
Cell Projection
Synapse
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Beta-catenin-TCF7L2 Complex
Cell Periphery
Beta-catenin-TCF Complex
Wnt Signalosome
Molecular Function
RNA Polymerase II Transcription Factor Binding
Protease Binding
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Beta-catenin Binding
Kinase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Dynactin Binding
Tau Protein Binding
Tau-protein Kinase Activity
NF-kappaB Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
Chromatin Binding
Transcription Coactivator Activity
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Enzyme Binding
Kinase Binding
Protein Phosphatase Binding
Estrogen Receptor Binding
Nuclear Hormone Receptor Binding
Ion Channel Binding
Alpha-catenin Binding
Cadherin Binding
SMAD Binding
I-SMAD Binding
Biological Process
Epithelial To Mesenchymal Transition
Positive Regulation Of Cell-matrix Adhesion
Glycogen Metabolic Process
Protein Phosphorylation
ER Overload Response
Signal Transduction
Dopamine Receptor Signaling Pathway
Circadian Rhythm
Insulin Receptor Signaling Pathway
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Positive Regulation Of Mitochondrion Organization
Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Hippocampus Development
Establishment Of Cell Polarity
Maintenance Of Cell Polarity
Regulation Of Axon Extension
Neuron Projection Development
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Phosphoprotein Phosphatase Activity
Regulation Of Microtubule-based Process
Intracellular Signal Transduction
Cellular Response To Interleukin-3
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Protein Catabolic Process
Protein Autophosphorylation
Positive Regulation Of Protein Export From Nucleus
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Excitatory Postsynaptic Potential
Regulation Of Microtubule Cytoskeleton Organization
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Superior Temporal Gyrus Development
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Neuron Projection Organization
Regulation Of Microtubule Anchoring At Centrosome
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Negative Regulation Of Neuron Death
Positive Regulation Of Neuron Death
Negative Regulation Of Protein Acetylation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Dopaminergic Neuron Differentiation
Cellular Response To Amyloid-beta
Positive Regulation Of Protein Localization To Centrosome
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Negative Regulation Of Type B Pancreatic Cell Development
Regulation Of Synaptic Vesicle Exocytosis
Negative Regulation Of Glycogen (starch) Synthase Activity
Protein Polyubiquitination
Branching Involved In Blood Vessel Morphogenesis
Epithelial To Mesenchymal Transition
Positive Regulation Of Neuroblast Proliferation
Cell Adhesion
Wnt Signaling Pathway, Calcium Modulating Pathway
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Viral Process
Wnt Signaling Pathway
Negative Regulation Of Angiogenesis
Stem Cell Population Maintenance
Regulation Of Centriole-centriole Cohesion
Response To Estradiol
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Protein Sumoylation
Adherens Junction Assembly
Protein Localization To Cell Surface
Hair Cell Differentiation
Entry Of Bacterium Into Host Cell
Detection Of Muscle Stretch
Embryonic Skeletal Limb Joint Morphogenesis
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Regulation Of Angiogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Regulation Of Fibroblast Proliferation
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Neurogenesis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Histone H3-K4 Methylation
Canonical Wnt Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Endothelial Tube Morphogenesis
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Sympathetic Ganglion Development
Regulation Of Centromeric Sister Chromatid Cohesion
Cellular Response To Growth Factor Stimulus
Cellular Response To Indole-3-methanol
Regulation Of Nephron Tubule Epithelial Cell Differentiation
Regulation Of Calcium Ion Import
Cell-cell Adhesion
Positive Regulation Of Core Promoter Binding
Beta-catenin-TCF Complex Assembly
Beta-catenin Destruction Complex Disassembly
Midbrain Dopaminergic Neuron Differentiation
Canonical Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Neuron Projection Extension
Regulation Of Protein Localization To Cell Surface
Positive Regulation Of DNA-templated Transcription, Initiation
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
B-WICH complex positively regulates rRNA expression
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Constitutive Signaling by AKT1 E17K in Cancer
Ubiquitin-dependent degradation of Cyclin D
Regulation of RUNX2 expression and activity
Replication of the SARS-CoV-1 genome
Maturation of nucleoprotein
Maturation of nucleoprotein
Maturation of nucleoprotein
Replication of the SARS-CoV-2 genome
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Apoptotic cleavage of cell adhesion proteins
Deactivation of the beta-catenin transactivating complex
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Ca2+ pathway
Adherens junctions interactions
Binding of TCF/LEF:CTNNB1 to target gene promoters
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability
Myogenesis
Myogenesis
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
RHO GTPases activate IQGAPs
Transcriptional Regulation by VENTX
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX3 regulates WNT signaling
Drugs
Lithium cation
3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
SB-409513
AR-AO-14418
Staurosporine
Indirubin-3'-monoxime
6-bromoindirubin-3'-oxime
Alsterpaullone
Phosphoaminophosphonic Acid-Adenylate Ester
2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Fostamatinib
Tideglusib
Lithium citrate
Lithium succinate
Lithium carbonate
Urea
Diseases
Gastric cancer
Colorectal cancer
Endometrial Cancer
Pilomatricoma; Epithelioma calcificans of Malherbe
Thyroid cancer
Hepatocellular carcinoma
GWAS
HDL cholesterol (
24097068
)
HDL cholesterol levels (
28334899
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Low density lipoprotein cholesterol levels (
32154731
)
Neutrophil count (
32888494
)
Platelet distribution width (
32888494
)
Bone mineral density (hip) (
27311723
19801982
)
Bone mineral density (total hip) (
29883787
)
Colorectal cancer (
26151821
)
Colorectal cancer or advanced adenoma (
30510241
)
Femoral neck bone mineral density (
29499414
22504420
)
Fractures (
30158200
)
Heel bone mineral density (
30598549
28869591
)
High myopia (
31816047
)
Lumbar spine bone mineral density (
29499414
)
Refractive error (
32231278
)
Systolic blood pressure (
30224653
)
Interacting Genes
225 interacting genes:
ACLY
ACSBG1
ACTL6B
ADAP1
ADIRF
AKAP11
AKT1
AKT2
AKT3
APC
APP
AR
ARRB1
ASRGL1
ATP5IF1
ATXN3
AURKA
AXIN1
AXIN2
BAG6
BCL2A1
BCL2L1
BCL3
BEX1
BHLHE41
BICD1
BICD2
BRIX1
BTRC
BZW2
CABYR
CAMSAP3
CCND1
CCNE1
CDH1
CDK5
CDX2
CEBPA
CEBPD
CEBPZ
CENPB
CHD3
CIITA
CLEC3B
CREB1
CREB3L3
CREM
CSAD
CSNK2B
CST6
CTNNB1
CTNND1
DBI
DCTN1
DCTN2
DCTN3
DDIT4
DEAF1
DEFA1
DELEC1
DHX34
DISC1
DNAJC13
DNM1L
DNMT1
DNMT3L
DPYSL2
DUSP9
DYNC1I1
E2F1
EEF1G
EFTUD2
EIF2B5
EIF4EBP1
ENTPD6
ERG28
EYA1
FAM193B
FAM83D
FBN3
FBXO7
FBXW11
FEN1
FIBP
FKBP14
FOXO1
FRAT1
FRAT2
FZD5
GBP2
GFI1
GIPC1
GJB5
GNB2
GPR39
GYS1
HDAC4
HNRNPD
HSP90AA1
HSPA4
IGHM
IGSF21
IKBKG
ILK
IQCG
IRF1
JUN
KDM1A
KHSRP
KIAA1191
KIF5B
KLF2
KLF5
LMO4
LPCAT1
LRP6
LUC7L2
MAP1B
MAP3K1
MAP3K4
MAP4
MAPK1
MAPT
MARK2
MASP1
MCL1
MDM2
MED24
MICAL1
MID1IP1
MITF
MPP1
MTF2
MTOR
MUC1
MYC
MYOCD
NAT9
NBR1
NCOA3
NDRG1
NFE2L1
NFE2L2
NFE2L3
NFKB1
NIN
NOTCH1
NOTCH2
NRBP1
NSFL1C
OGA
OGT
PDE4D
PFKFB4
PHLPP1
PIAS1
PIM2
PMAIP1
PPARGC1A
PPP1R2
PRKACA
PRKCA
PRKCB
PRKCZ
PRKDC
PSEN1
PTK2
PTN
PTPN1
PXN
QARS1
RAI1
RBPJ
RCAN1
RELB
RICTOR
RPL36AL
RPLP1
RPS2
RPS6KA1
RSU1
RXRA
SAP30BP
SGK1
SGK3
SLA
SMAD3
SNAI1
SNCA
SNCAIP
SOX10
SPTBN4
SREBF1
STAT2
SYNE4
TAZ
TLE1
TMEM132A
TMEM44
TNFAIP3
TONSL
TP53
TPPP
TRAF6
TSC2
TUBA1A
UBE2D1
UBR1
UBR5
UBXN6
UFM1
UPF3A
VIM
VPS51
WSB1
XIAP
XPNPEP1
YBX1
YBX3
YWHAZ
ZFPM1
ZHX1
ZNF135
ZNF227
ZNF746
187 interacting genes:
ACP1
AJAP1
AKT1
AMER1
APC
APC2
APP
AR
ARFGEF1
ARHGAP32
ASH2L
AXIN1
AXIN2
BCL3
BCL6
BCL9
BCL9L
BOC
BRCA1
BTRC
CA9
CARM1
CASP3
CASP8
CBL
CBY1
CCND1
CDC27
CDC34
CDC73
CDH1
CDH11
CDH15
CDH16
CDH2
CDH24
CDH3
CDH5
CDH7
CDH8
CDH9
CDK2
CDK5R1
CDK6
CDON
CEBPA
CHD8
CHUK
CREBBP
CSNK1A1
CSNK1D
CSNK2A1
CSNK2B
CTNNA1
CTNNA3
CTNNBIP1
CTNND2
DLG5
DSC3
DVL1
DVL3
EGFR
ELAVL1
EP300
ERBB2
ERBIN
ESR1
EZR
FBXW2
FER
FHIT
FHL2
FLT1
FOXO1
FOXO4
FSCN1
FUS
FYN
GLIS2
GNA13
GRIK2
GRIN1
GRIN2D
GSK3B
H1-2
HIF1A
HNF1A
HUWE1
IGF2BP1
IKBKB
IQGAP1
JADE1
KAT2A
KAT2B
KDR
KMT2A
KMT2D
LATS2
LEF1
LEO1
MAGI1
MAGI2
MAP3K2
MAPK8
MAPK9
MEN1
MET
MITF
MUC1
NCOA2
NDRG1
NEK2
NEURL2
NF2
NFKB1
NOTCH1
NR5A1
PECAM1
PICK1
PIK3R1
PIN1
PITX2
PKD1
PKM
PKP2
PLK1
PPM1A
PRKCG
PSEN1
PSEN2
PTGS2
PTPN1
PTPN13
PTPN14
PTPN6
PTPRF
PTPRJ
PTPRK
PTPRM
PTPRU
PTPRZ1
PYGO1
RAPGEF2
RBBP5
RUVBL1
RUVBL2
RXRA
SALL1
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCA4
SMARCA5
SMURF1
SOX1
SOX17
SP1
SPN
SRC
STUB1
TAX1BP3
TBL1X
TCF3
TCF4
TCF7L1
TCF7L2
TFAP2A
TGFBR1
TGFBR2
TLE1
TRIM33
TRIM55
TRIM63
TRIP10
TRRAP
UBE2B
UBE2D1
UBE2R2
UBE2S
UBE3A
UHRF2
USP2
USP9X
ZFYVE9
ZIC3
Entrez ID
2932
1499
HPRD ID
05418
00286
Ensembl ID
ENSG00000082701
ENSG00000168036
Uniprot IDs
P49841
Q6FI27
A0A024R2Q3
B4DGU4
P35222
PDB IDs
1GNG
1H8F
1I09
1J1B
1J1C
1O6K
1O6L
1O9U
1PYX
1Q3D
1Q3W
1Q41
1Q4L
1Q5K
1R0E
1UV5
2JDO
2JDR
2JLD
2O5K
2OW3
2UW9
2X39
2XH5
3CQU
3CQW
3DU8
3E87
3E88
3E8D
3F7Z
3F88
3GB2
3I4B
3L1S
3M1S
3MV5
3OW4
3PUP
3Q3B
3QKK
3SAY
3SD0
3ZDI
3ZRK
3ZRL
3ZRM
4ACC
4ACD
4ACG
4ACH
4AFJ
4B7T
4DIT
4EKK
4IQ6
4J1R
4J71
4NM0
4NM3
4NM5
4NM7
4PTC
4PTE
4PTG
5F94
5F95
5HLN
5HLP
5K5N
5KPK
5KPL
5KPM
5OY4
5T31
6B8J
6BUU
6GJO
6GN1
6H0U
6HK3
6HK4
6HK7
6NPZ
6TCU
6V6L
6Y9R
6Y9S
1G3J
1JDH
1JPW
1LUJ
1P22
1QZ7
1T08
1TH1
2G57
2GL7
2Z6H
3DIW
3FQN
3FQR
3SL9
3SLA
3TX7
4DJS
6M90
6M91
6M92
6M93
6M94
6O9B
6O9C
6WLX
6WNX
Enriched GO Terms of Interacting Partners
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