GRM2 and RGS12

Data Source:
HPRD (in vitro)

		GRM2	RGS12
Description		glutamate metabotropic receptor 2	regulator of G protein signaling 12
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Presynaptic Membrane Astrocyte Projection Integral Component Of Postsynaptic Membrane	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Synapse
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Protein Kinase B Signaling Regulation Of Synaptic Transmission, Glutamatergic Glutamate Homeostasis	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	G alpha (i) signalling events G alpha (i) signalling events
Drugs		LY2140023
Diseases
GWAS			Adult body size ( 32376654) Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Hepatocyte growth factor levels ( 25998175) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Platelet count ( 29403010) Serum albumin level ( 29403010) Total cholesterol levels ( 29403010) Tuberculosis ( 29036319) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		29 interacting genes: ACBD5 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MFSD14B MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 STOM TAMALIN TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG
Entrez ID		2912	6002
HPRD ID		04977	03943
Ensembl ID		ENSG00000164082	ENSG00000159788
Uniprot IDs		Q14416	O14924
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ	2EBZ 2KV8
Enriched GO Terms of Interacting Partners?
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