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GRM2 and SDCBP
Data Source:
BioGRID
(pull down)
GRM2
SDCBP
Description
glutamate metabotropic receptor 2
syndecan binding protein
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Axon
Dendrite
Presynaptic Membrane
Astrocyte Projection
Integral Component Of Postsynaptic Membrane
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Interleukin-5 Receptor Complex
Adherens Junction
Focal Adhesion
Membrane
Nuclear Membrane
Azurophil Granule Lumen
Melanosome
Membrane Raft
Synapse
Extracellular Exosome
Blood Microparticle
Extracellular Vesicle
Molecular Function
Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity
Group II Metabotropic Glutamate Receptor Activity
G Protein-coupled Receptor Activity
Calcium Channel Regulator Activity
Protein Binding
Glutamate Receptor Activity
Scaffold Protein Binding
Frizzled Binding
Interleukin-5 Receptor Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Cytoskeletal Anchor Activity
Identical Protein Binding
Syndecan Binding
Protein Heterodimerization Activity
Protein N-terminus Binding
Biological Process
G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway
G Protein-coupled Glutamate Receptor Signaling Pathway
Chemical Synaptic Transmission
Gene Expression
Glutamate Secretion
Regulation Of Protein Kinase B Signaling
Regulation Of Synaptic Transmission, Glutamatergic
Glutamate Homeostasis
Negative Regulation Of Receptor Internalization
Protein Targeting To Membrane
Substrate-dependent Cell Migration, Cell Extension
Chemical Synaptic Transmission
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Actin Cytoskeleton Organization
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intracellular Signal Transduction
Positive Regulation Of Phosphorylation
Neutrophil Degranulation
Positive Regulation Of JNK Cascade
Ephrin Receptor Signaling Pathway
Positive Regulation Of Exosomal Secretion
Positive Regulation Of Extracellular Exosome Assembly
Pathways
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Ephrin signaling
Neurofascin interactions
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
Neutrophil degranulation
Drugs
LY2140023
Diseases
GWAS
Low density lipoprotein cholesterol levels (
32154731
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Triglyceride levels (
32154731
)
Interacting Genes
29 interacting genes:
ACBD5
AQP6
BIK
CCDC107
CLDN2
CLDN9
CPLX4
CYB5R3
GNA15
GNAQ
GRIP1
LMNA
MFSD14B
MGST3
MMGT1
NAALADL2
PDZK1IP1
RGS12
SAR1A
SDCBP
SLC30A8
SLC38A1
STOM
TAMALIN
TMEM130
TMEM237
TMEM248
TSPAN18
UBQLN1
307 interacting genes:
ABI2
ANKRD33
ANKRD36B
ANKRD40
ANP32B
APIP
ARFIP2
ARL6IP1
BCL2L15
BEND7
C11orf68
C1orf109
C1orf35
C2CD2L
CABP5
CADM1
CADPS
CALCOCO2
CALM1
CALM2
CALM3
CAV2
CBR3
CBY2
CCDC102B
CCDC106
CD6
CD63
CDA
CDC34
CDCP1
CDIPT
CDKN2D
CEP55
CEP85
CGGBP1
CHIC2
CHMP1A
CLK2
CLK3
CMTM5
COX4I1
CRX
CRYAA
CRYAA2
CT45A1
CT45A10
CT45A3
CT45A5
CTBP2
CTDSP1
CUTC
CYHR1
DCTD
DCTPP1
DDX39B
DERL3
DMC1
DNM2
DRAP1
DTNBP1
DYNLT1
EAF1
EDARADD
EFNB1
EFNB2
EIF1AD
EIF5A
EIF5A2
ELAVL1
EMILIN3
ENOX1
ENTR1
EPHB2
ERICH2
EXOSC4
FADD
FAM118A
FAM118B
FAM9A
FAM9B
FHL3
FHL5
FLAD1
FOXP2
FTH1
FTL
GET4
GGPS1
GKAP1
GNMT
GOLT1B
GPATCH11
GPR37
GRIA1
GRIA2
GRIA3
GRIA4
GRIK1
GRIK2
GRM2
GRM3
GRM7
GRXCR1
GSC2
GSG1
HEXIM2
HHAT
HIVEP1
HMBOX1
HMGB3
HNRNPC
HOMER3
HOMEZ
HOXA1
HOXA7
HPRT1
HSBP1
HSF2BP
HUS1
ID3
IGFBP6
IHO1
IKZF1
IL5RA
INO80E
KATNBL1
KCNH1
KCNJ2
KCTD1
KCTD6
KCTD9
KHDRBS2
KLHL12
KLHL2
KRT14
KRTAP1-3
KRTAP1-5
KRTAP10-3
KRTAP10-7
KRTAP5-9
LDB2
LDHB
LDOC1
LEPROTL1
LGALS2
LSM6
LURAP1L
LZTFL1
MAD2L1
MAPK9
MAPRE3
MATN4
MBD3
MED4
MEOX1
MEOX2
MGLL
MID2
MINDY3
MKRN1
MOBP
MRFAP1
MRFAP1L1
MTUS2
MYBPC2
MYLIP
N4BP3
NADK
NAGK
NAPB
NECAB2
NF2
NFASC
NKAPD1
NOTCH2NLA
NT5C2
OCM
ODAM
OPTN
OSTF1
PCBD1
PCYT1A
PDCD6IP
PDE4DIP
PDE9A
PDLIM4
PDZK1IP1
PFDN5
PHC2
PHF11
PIH1D2
PNMA1
PNMA2
POLR2J
POLR3K
PPARA
PRPF38A
PRPF40A
PRR13
PSMB3
PSMC6
PSME2
PSTPIP1
PTEN
PTPRJ
PTS
PUF60
PYCR3
RAB5A
RALY
RBM39
REEP6
REL
RIC8A
RNF11
RNH1
ROPN1
RP9
RP9P
RPIA
RPL22
RPRD1A
RPRM
RPS26
RRM2
RRS1
RTL8B
RTN1
RUNDC3A
S100B
SCG3
SCML1
SDC1
SDC2
SDC4
SDCBP2
SEPTIN1
SEPTIN3
SET
SFT2D1
SIAH1
SLC50A1
SLC6A5
SMARCA2
SNRPA
SNX1
SOX4
SPANXN3
SREK1IP1
SRSF11
SRSF3
SRSF7
SSC5D
SSNA1
STX1A
SUB1
SULT1B1
SYNGR1
SYPL1
SYS1
TCF21
TCF4
TDO2
TEKT1
TFCP2
TGFA
THG1L
TIFA
TKFC
TLE5
TMCO2
TMEM17
TMEM239
TNFAIP8
TNFAIP8L3
TNKS
TRAF5
TRARG1
TRIM27
TRIM32
TRIM38
TRIM54
TRIP13
TSN
UBB
UBC
UBE2A
UBE2K
UBE2R2
ULK1
WASHC1
WASHC3
WASL
WDR91
YIF1A
ZBTB14
ZBTB8A
ZCCHC10
ZCCHC17
ZMYND12
ZNF343
ZNF485
ZNF660
ZNF768
ZRANB1
ZSCAN23
Entrez ID
2912
6386
HPRD ID
04977
03741
Ensembl ID
ENSG00000164082
ENSG00000137575
Uniprot IDs
Q14416
A0A024R7Z5
B4DHN5
G5EA09
O00560
PDB IDs
4XAQ
4XAS
5CNI
5CNJ
5KZN
5KZQ
1N99
1NTE
1OBX
1OBY
1OBZ
1R6J
1V1T
1W9E
1W9O
1W9Q
1YBO
4Z33
Enriched GO Terms of Interacting Partners
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