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GRIK2 and DLG1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
GRIK2
DLG1
Description
glutamate ionotropic receptor kainate type subunit 2
discs large MAGUK scaffold protein 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Postsynaptic Density
Dendrite Cytoplasm
Kainate Selective Glutamate Receptor Complex
Presynaptic Membrane
Terminal Bouton
Perikaryon
Postsynaptic Membrane
Hippocampal Mossy Fiber To CA3 Synapse
Glutamatergic Synapse
Immunological Synapse
Basement Membrane
Nucleus
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Microtubule
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Ionotropic Glutamate Receptor Complex
Cytoplasmic Side Of Plasma Membrane
Intercalated Disc
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Cell Junction
Cell Projection Membrane
Neuromuscular Junction
Node Of Ranvier
Myelin Sheath Abaxonal Region
Sarcolemma
Neuron Projection
Lateral Loop
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
MPP7-DLG1-LIN7 Complex
Synaptic Membrane
Postsynaptic Density Membrane
Glutamatergic Synapse
Molecular Function
Extracellularly Glutamate-gated Ion Channel Activity
Glutamate Receptor Activity
Ligand-gated Ion Channel Activity
Kainate Selective Glutamate Receptor Activity
PDZ Domain Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Identical Protein Binding
Ligand-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
Guanylate Kinase Activity
Phosphoprotein Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Cytoskeletal Protein Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Binding
Ion Channel Binding
Cadherin Binding
Molecular Adaptor Activity
L27 Domain Binding
Structural Constituent Of Postsynaptic Density
Biological Process
Behavioral Fear Response
Cellular Calcium Ion Homeostasis
Glutamate Receptor Signaling Pathway
Chemical Synaptic Transmission
Neuronal Action Potential
Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Receptor Clustering
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Regulation Of JNK Cascade
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Short-term Neuronal Synaptic Plasticity
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Synaptic Transmission
Neuron Apoptotic Process
Negative Regulation Of Synaptic Transmission, Glutamatergic
Excitatory Postsynaptic Potential
Inhibitory Postsynaptic Potential
Regulation Of Presynaptic Membrane Potential
Detection Of Cold Stimulus Involved In Thermoception
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
Immunological Synapse Formation
Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Protein Dephosphorylation
Actin Filament Organization
Establishment Or Maintenance Of Cell Polarity
Chemical Synaptic Transmission
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Embryo Development
Viral Process
Peristalsis
Positive Regulation Of Actin Filament Polymerization
Cortical Actin Cytoskeleton Organization
Astral Microtubule Organization
Membrane Raft Organization
Regulation Of Myelination
Activation Of Protein Kinase Activity
Cellular Protein-containing Complex Localization
T Cell Activation
Negative Regulation Of T Cell Proliferation
Regulation Of Membrane Potential
Amyloid Precursor Protein Metabolic Process
Receptor Clustering
Positive Regulation Of Potassium Ion Transport
Cortical Microtubule Organization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
GMP Metabolic Process
GDP Metabolic Process
Reproductive Structure Development
Embryonic Skeletal System Morphogenesis
Smooth Muscle Tissue Development
Negative Regulation Of Epithelial Cell Proliferation
Establishment Of Centrosome Localization
Negative Regulation Of Protein Kinase B Signaling
Hard Palate Development
Negative Regulation Of ERK1 And ERK2 Cascade
Bicellular Tight Junction Assembly
Protein Localization To Plasma Membrane
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Maintenance Of Postsynaptic Density Structure
Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Protein Localization To Synapse
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of Potassium Ion Import
Negative Regulation Of P38MAPK Cascade
Regulation Of Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of NMDA Receptor Activity
Pathways
Activation of Na-permeable kainate receptors
Activation of Ca-permeable Kainate Receptor
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Glutamic acid
Butabarbital
Butalbital
Topiramate
Talbutal
Pentobarbital
Secobarbital
Metharbital
Thiopental
Primidone
Methylphenobarbital
Phenobarbital
Amobarbital
Aprobarbital
Butobarbital
Heptabarbital
Hexobarbital
Barbital
Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione
Domoic Acid
Quisqualic acid
2s,4r-4-Methylglutamate
Diseases
Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS
Age-related cognitive decline (language) (slope of z-scores) (
30954325
)
Biochemical measures (
19260141
)
Cardiac hypertrophy (
21348951
)
Emphysema imaging phenotypes (
26030696
)
Heart rate response to recovery post exercise (20 sec) (
29497042
)
Longevity (90 years and older) (
25199915
)
Obesity-related traits (
23251661
)
Obsessive-compulsive disorder (
22889921
)
Palmitic acid (16:0) levels (
23362303
)
Pursuit maintenance gain (
29064472
)
Renal function-related traits (eGRFcrea) (
22797727
)
Weight (
28552196
)
Allergic rhinitis (
25085501
)
Diastolic blood pressure (
30224653
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Interacting Genes
18 interacting genes:
CALCOCO1
CASK
CDH2
CTNNB1
CTNND1
DLG1
DLG3
DLG4
GRIA1
GRID2
GRIK4
GRIK5
GRIP1
LIN7B
PICK1
PRKAA1
SDCBP
TRIM25
75 interacting genes:
ACTA1
ACTN2
ADAM17
ADGRA2
ADGRA3
ADGRB1
ADRB1
AKAP5
ATP2B2
ATP2B4
BCR
BEGAIN
CACNG2
CALM2
CAMK2A
CASK
CNKSR2
CRHR1
CRIPT
CTNNA1
DLG2
DLG3
DLGAP1
DLGAP3
DLGAP4
EPB41
ERBB4
EZR
FZD4
FZD7
GDA
GLS2
GNG13
GRIA1
GRIK2
GRIN1
GRIN2A
GRIN2B
GUCY1A2
HTR2A
KCNA1
KCNA2
KCNA3
KCNA4
KCNA5
KCNAB1
KCNJ10
KCNJ12
KCNJ2
KCNJ4
KCNJ6
KHDRBS1
KIF13B
KIF1B
LCK
LRP2
LRRC1
MAP1A
MAPK12
MPP2
MRPS34
MYO6
PAX6
PBK
PRKN
PTEN
SCN4A
SCN5A
SEMA4C
STX4
TANC1
TJAP1
UBE3A
WAS
WNT3A
Entrez ID
2898
1739
HPRD ID
00692
03007
Ensembl ID
ENSG00000164418
ENSG00000075711
Uniprot IDs
A8K0H7
Q13002
Q8IY40
A0A0C4DFT3
A0A590UJ08
B4DF78
Q12959
PDB IDs
3QXM
5CMM
1PDR
2M3M
2OQS
2X7Z
3LRA
3RL7
3RL8
3W9Y
4AMH
4G69
Enriched GO Terms of Interacting Partners
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