TRIM59 and OTOL1

Data Source:
BioGRID (two hybrid)

		TRIM59	OTOL1
Description		tripartite motif containing 59	otolin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B	Extracellular Region Collagen Type IV Trimer Extracellular Space Extracellular Matrix
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Otolith Mineralization Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Adventurousness ( 30643258) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Aging (time to death) ( 21782286) Alcohol consumption (drinks per week) ( 30643258) Hepcidin/ferritin ratio ( 27846281) Schizophrenia ( 28991256 30285260) Type 2 diabetes ( 30130595)
Interacting Genes		26 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PLLP RASSF3 RHOU SEC22A SNAP47 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		286827	131149
HPRD ID		15568	19083
Ensembl ID		ENSG00000213186	ENSG00000182447
Uniprot IDs		Q8IWR1	A6NHN0
PDB IDs
Enriched GO Terms of Interacting Partners?
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