GPLD1 and GM2A

Data Source:
HPRD (in vitro)

		GPLD1	GM2A
Description		glycosylphosphatidylinositol specific phospholipase D1	GM2 ganglioside activator
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosomal Membrane Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Region Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Sodium Channel Regulator Activity	Lipid Transporter Activity Phospholipase Activator Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway C-terminal Protein Lipidation GPI Anchor Release Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Cellular Response To Drug Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Secretion Transepithelial Transport Cellular Response To Calcium Ion Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Neutrophil Degranulation Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Glycosphingolipid metabolism Neutrophil degranulation
Drugs			Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases			GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 31666285 29403010)	Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)
Interacting Genes		5 interacting genes: ALPP APOA1 APOA4 CD55 GM2A	3 interacting genes: GPLD1 HEXA PLD2
Entrez ID		2822	2760
HPRD ID		03946	02034
Ensembl ID		ENSG00000112293	ENSG00000196743
Uniprot IDs		P80108	P17900
PDB IDs			1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?
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