GPLD1 and APOA1

Data Source:
HPRD (in vitro, in vivo)

		GPLD1	APOA1
Description		glycosylphosphatidylinositol specific phospholipase D1	apolipoprotein A1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosomal Membrane Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Sodium Channel Regulator Activity	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Chemorepellent Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway C-terminal Protein Lipidation GPI Anchor Release Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Cellular Response To Drug Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Secretion Transepithelial Transport Cellular Response To Calcium Ion Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus	Retinoid Metabolic Process Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Platelet Degranulation Negative Regulation Of Cytokine Production Involved In Immune Response Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Esterification Positive Regulation Of Cholesterol Efflux Positive Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Peripheral Nervous System Axon Regeneration Protein Oxidation Peptidyl-methionine Modification Regulation Of Lipid Metabolic Process Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Animal Organ Regeneration Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Response To Drug Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Response To Estrogen Post-translational Protein Modification Reverse Cholesterol Transport Cellular Protein Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Positive Regulation Of Lipoprotein Lipase Activity Vitamin Transport Positive Regulation Of Hydrolase Activity Positive Regulation Of Stress Fiber Assembly Transmembrane Transport Phospholipid Homeostasis Negative Regulation Of Lipase Activity Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Intermembrane Lipid Transfer Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Hypoalphalipoproteinemia Familial amyloidosis
GWAS		Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 31666285 29403010)	Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Body mass index ( 31978080) Cholesterol, total ( 24097068 19060911 20686565) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Diastolic blood pressure ( 27841878) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 24097068 20864672 19060906 20686565 26582766) HDL cholesterol levels ( 28334899) Hearing function ( 25060954) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 27599772 23505323) Infantile hypertrophic pyloric stenosis ( 23989729) LDL cholesterol ( 24097068 18179892 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 26763881 28371326 28548082) Triglycerides ( 24097068 19074352 21909109 18193043 18193044 18193046 20864672 19060906 19060911 20139978 20686565 26582766) Very low density lipoprotein cholesterol levels ( 28548082)
Interacting Genes		5 interacting genes: ALPP APOA1 APOA4 CD55 GM2A	38 interacting genes: ABCA1 ABCA13 AKT2 APOA2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HP HPR JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SAA2 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TTR VKORC1
Entrez ID		2822	335
HPRD ID		03946	02517
Ensembl ID		ENSG00000112293	ENSG00000118137
Uniprot IDs		P80108	A0A024R3E3 P02647
PDB IDs			1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F
Enriched GO Terms of Interacting Partners?
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