GPLD1 and APOA4

Data Source:
HPRD (in vivo, in vitro)

		GPLD1	APOA4
Description		glycosylphosphatidylinositol specific phospholipase D1	apolipoprotein A4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosomal Membrane Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Cell Surface Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Sodium Channel Regulator Activity	Lipid Transporter Activity Copper Ion Binding Protein Binding Phospholipid Binding Lipid Binding Cholesterol Binding Antioxidant Activity Phosphatidylcholine Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Cholesterol Transfer Activity
	Biological Process	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway C-terminal Protein Lipidation GPI Anchor Release Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Cellular Response To Drug Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Secretion Transepithelial Transport Cellular Response To Calcium Ion Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus	Retinoid Metabolic Process Innate Immune Response In Mucosa Cholesterol Biosynthetic Process Lipid Transport Response To Lipid Hydroperoxide Leukocyte Cell-cell Adhesion Cholesterol Metabolic Process Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Removal Of Superoxide Radicals Regulation Of Intestinal Cholesterol Absorption Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly High-density Lipoprotein Particle Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Stilbenoid Lipoprotein Metabolic Process Cholesterol Homeostasis Hydrogen Peroxide Catabolic Process Reverse Cholesterol Transport Cellular Protein Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Protein-lipid Complex Assembly Triglyceride Homeostasis Intermembrane Lipid Transfer
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Chylomicron assembly Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs			Zinc Copper Zinc acetate
Diseases
GWAS		Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 31666285 29403010)	Apolipoprotein A-IV levels ( 27412012) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary artery disease ( 29263402) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 20864672 19060906 20686565 26582766) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolic syndrome ( 30382898) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Total cholesterol levels ( 28334899 29403010 29615537) Triglyceride levels ( 32203549 28334899 26763881 28371326 29615537 32335043) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565 26582766)
Interacting Genes		5 interacting genes: ALPP APOA1 APOA4 CD55 GM2A	5 interacting genes: AGTRAP CMTM4 CMTM5 GPLD1 MAGEA6
Entrez ID		2822	337
HPRD ID		03946	00130
Ensembl ID		ENSG00000112293	ENSG00000110244
Uniprot IDs		P80108	P06727
PDB IDs			3S84
Enriched GO Terms of Interacting Partners?
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