GLDC and TLR10

Data Source:
HPRD (two hybrid)

		GLDC	TLR10
Description		glycine decarboxylase	toll like receptor 10
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Glycine Binding Lyase Activity Enzyme Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Electron Transport Chain Response To Methylamine Protein-containing Complex Assembly Response To Lipoic Acid	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response
Pathways		Glycine degradation	Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs		Pyridoxal phosphate
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 31070104 30837465) Height ( 31562340) Metabolite levels ( 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Urinary metabolite levels in chronic kidney disease ( 31959995)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		1 interacting genes: TLR10	12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54
Entrez ID		2731	81793
HPRD ID		01996	05884
Ensembl ID		ENSG00000178445	ENSG00000174123
Uniprot IDs		P23378	A0A024R9W4 Q9BXR5
PDB IDs		6I33 6I34 6I35	2J67
Enriched GO Terms of Interacting Partners?
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