ARHGEF16 and TNFRSF18

Data Source:
BioGRID (proximity labelling technology)

		ARHGEF16	TNFRSF18
Description		Rho guanine nucleotide exchange factor 16	TNF receptor superfamily member 18
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding	Tumor Necrosis Factor-activated Receptor Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Response to statin therapy ( 20339536)	Inflammatory bowel disease ( 23128233)
Interacting Genes		9 interacting genes: CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TFG YWHAQ	6 interacting genes: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2
Entrez ID		27237	8784
HPRD ID		12478	04879
Ensembl ID		ENSG00000130762	ENSG00000186891
Uniprot IDs		B3KTS4 Q5VV41	A0A0R7FDM1 Q9Y5U5
PDB IDs		1X6B
Enriched GO Terms of Interacting Partners?
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