ARHGEF16 and CKAP5

Data Source:
BioGRID (pull down)

		ARHGEF16	CKAP5
Description		Rho guanine nucleotide exchange factor 16	cytoskeleton associated protein 5
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GO Annotations	Cellular Component	Cytosol	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Gamma-tubulin Complex Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding	Protein Binding Microtubule Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus End Polymerase
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane	G2/M Transition Of Mitotic Cell Cycle Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Response to statin therapy ( 20339536)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656)
Interacting Genes		9 interacting genes: CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TFG YWHAQ	11 interacting genes: ARHGEF16 AURKA CACNA1A CLASP1 CLK1 NDC80 PTPRN2 SLAIN2 SUMO2 TOP1 USP19
Entrez ID		27237	9793
HPRD ID		12478	10830
Ensembl ID		ENSG00000130762	ENSG00000175216
Uniprot IDs		B3KTS4 Q5VV41	Q14008
PDB IDs		1X6B	4QMI 4QMJ
Enriched GO Terms of Interacting Partners?
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