TNFRSF18 and TNFSF18

Data Source:
HPRD (in vivo)

		TNFRSF18	TNFSF18
Description		TNF receptor superfamily member 18	TNF superfamily member 18
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion	Adaptive Immune Response T Cell Proliferation Involved In Immune Response Positive Regulation Of Leukocyte Migration Signal Transduction Cell-cell Signaling Positive Regulation Of Macrophage Chemotaxis Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Dendritic Cell Chemotaxis
Pathways		TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 27182965) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 22057235 20190752 24999842) Crohn's disease ( 21102463 23128233) Itch intensity from mosquito bite ( 28199695) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		6 interacting genes: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2	2 interacting genes: EXOC3L2 TNFRSF18
Entrez ID		8784	8995
HPRD ID		04879	04874
Ensembl ID		ENSG00000186891	ENSG00000120337
Uniprot IDs		A0A0R7FDM1 Q9Y5U5	A0A0U5JXL4 Q9UNG2
PDB IDs			2Q1M 2R30 2R32 3B93 3B94
Enriched GO Terms of Interacting Partners?
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