FRG1 and GNMT

Data Source:
BioGRID (two hybrid)

		FRG1	GNMT
Description		FSHD region gene 1	glycine N-methyltransferase
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GO Annotations	Cellular Component	Nucleolus Cajal Body Z Disc Striated Muscle Dense Body Catalytic Step 2 Spliceosome	Cytosol
	Molecular Function	RNA Binding Protein Binding Actin Filament Binding	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding
	Biological Process	MRNA Splicing, Via Spliceosome RRNA Processing Muscle Organ Development	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation Cellular Nitrogen Compound Metabolic Process S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process
Pathways			Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation
Drugs			Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases			Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Brain volume in infants (cerebrospinal fluid) ( 28763065) Periodontitis (CDC/AAP) ( 24024966) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		5 interacting genes: EXOSC8 GNMT KRT40 LZTS2 RBPMS	30 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337
Entrez ID		2483	27232
HPRD ID		03176	05970
Ensembl ID		ENSG00000109536	ENSG00000124713
Uniprot IDs		Q14331	A0A0S2Z5F2 Q14749 V9HW60
PDB IDs		6ZYM 7A5P	1R74 2AZT
Enriched GO Terms of Interacting Partners?
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