SERP1 and ALG3

Data Source:
BioGRID (two hybrid)

		SERP1	ALG3
Description		stress associated endoplasmic reticulum protein 1	ALG3 alpha-1,3- mannosyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Alpha-1,3-mannosyltransferase Activity Protein Binding Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol Alpha-1,3-mannosyltransferase Activity
	Biological Process	Cellular Protein Modification Process Protein Glycosylation Plasma Membrane Organization Protein Transport Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Mannosylation
Pathways		XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG3 causes ALG3-CDG (CDG-1d)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS			Major depressive disorder ( 22472876)
Interacting Genes		52 interacting genes: ALG3 APH1A APP AQP6 AQP8 BIK BSCL2 CANX CD74 CD79A CRB3 CYBRD1 EBP FAM174A FAM209A FAM210B FRMD3 GJB3 GJB5 GKN1 GPR37L1 GPX8 HSD17B13 IL3RA JAGN1 KCNF1 KIR3DL3 LHFPL5 LMNA MFSD14B MTIF3 PLPPR1 REEP4 SAR1A SCNN1A SCNN1G SEC11C SEC61A1 SEC61B SLC10A6 SLC22A1 SLC22A2 SLC35C2 SSMEM1 STX1A STX2 STX4 TLCD4 TMEM14B TMEM52B TMEM79 TNFRSF9	7 interacting genes: ARL13B CD79A CREB3 LMNA SERP1 SSMEM1 TMEM52B
Entrez ID		27230	10195
HPRD ID		18037	03067
Ensembl ID		ENSG00000120742	ENSG00000214160
Uniprot IDs		Q9Y6X1	C9J7S5 Q92685
PDB IDs
Enriched GO Terms of Interacting Partners?
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