DCTN2 and BORCS6

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		DCTN2	BORCS6
Description		dynactin subunit 2	BLOC-1 related complex subunit 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome	Lysosomal Membrane BORC Complex
	Molecular Function	Motor Activity Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Mitotic Metaphase Plate Congression Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking	Lysosome Localization
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Interacting Genes		35 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 BORCS6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 PAFAH1B1 RABGEF1 RINT1 RPGR SMARCD1 TXLNB USHBP1 ZW10	38 interacting genes: ABI2 BEX2 C19orf25 C1orf109 C1orf216 CCHCR1 DCTN2 DISC1 EPS8 EXOC8 EXOSC5 FAM161B FAM9C FBXO44 FCHSD2 GAS8 HAUS1 HGS INSYN1 KANK2 KXD1 LAMTOR2 LNX1 MED21 MOS NDEL1 NTAQ1 OSTF1 PKNOX1 PLA2G4A RCOR3 RIBC1 SHPRH SPG21 TACC2 USHBP1 VPS52 ZNF655
Entrez ID		10540	54785
HPRD ID		09568	13368
Ensembl ID		ENSG00000175203	ENSG00000196544
Uniprot IDs		A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58	Q96GS4
PDB IDs
Enriched GO Terms of Interacting Partners?
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